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首页> 外文期刊>Reproductive toxicology >Induction of micronuclei formation in preimplantation mouse embryos after maternal treatment with 2-bromopropane.
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Induction of micronuclei formation in preimplantation mouse embryos after maternal treatment with 2-bromopropane.

机译：用2-溴丙烷进行母体处理后，在植入前小鼠胚胎中诱导微核形成。

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摘要

We examined effects of 2-bromopropane (2-BP), a chlorofluorocarbon replacement, on mouse embryonic mutagenicity. 2-BP was administered to pregnant mice intraperitoneally (i.p.) (300, 600, 900, and 1800 mg/kg) during the early preimplantation period. On day 3 of gestation, micronuclei (MN) frequency and embryo cell number were determined. 2-BP induced a dose-related significant increase in MN frequency and a treatment-related decrease in embryo cell number. Furthermore, the cell numbers were significantly smaller in the MN-positive embryos by two-way ANOVA taking it into account an interactive effect between 2-BP dose and the presence or absence of MN. A simultaneous decrease in cell number and increase in MN frequency may reflect an embryonic developmental disadvantage resulting from maternal treatment with 2-BP. Further study is needed to establish how 2-BP contributes to postimplantation embryonic development.
机译：我们检查了2-溴丙烷（2-BP）（一种氯氟烃替代物）对小鼠胚胎致突变性的影响。在植入前早期，腹膜内（i.p.）（300、600、900和1800 mg / kg）将2-BP给予怀孕的小鼠。在妊娠的第3天，测定微核（MN）频率和胚胎细胞数。 2-BP诱导剂量相关的MN频率显着增加和与治疗相关的胚胎细胞数量减少。此外，考虑到2-BP剂量与MN的存在与否之间的相互作用，通过双向ANOVA分析，MN阳性胚胎中的细胞数量明显减少。细胞数目的同时减少和MN频率的增加可能反映了由2-BP的母体治疗导致的胚胎发育不利。需要进一步的研究来确定2-BP如何促进植入后的胚胎发育。

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