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首页> 外文期刊>Reproductive toxicology >Reproductive and developmental toxicity of natural and depleted uranium: a review.
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Reproductive and developmental toxicity of natural and depleted uranium: a review.

机译：天然铀和贫铀的生殖和发育毒性：综述。

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摘要

Although the biokinetics, metabolism, and chemical toxicity of uranium are well known, until recently little attention was paid to the potential toxic effects of uranium on reproduction and development in mammals. In recent years, it has been shown that uranium is a developmental toxicant when given orally or subcutaneously (SC) to mice. Decreased fertility, embryo/fetal toxicity including teratogenicity, and reduced growth of the offspring have been observed following uranium exposure at different gestation periods. The reproductive toxicity, maternal toxicity, embryo/fetal toxicity, and postnatal effects of uranium, as well as the prevention by chelating agents of uranium-induced maternal and developmental toxicity are reviewed here. Data on the toxic effects of depleted uranium on reproduction and development are also reviewed.
机译：尽管铀的生物动力学，代谢和化学毒性是众所周知的，但直到最近，铀对哺乳动物繁殖和发育的潜在毒性作用仍未引起足够的重视。近年来，已经证明，当对小鼠口服或皮下（SC）施用铀时，铀是一种发育性毒物。在不同妊娠期接触铀后，观察到生育力降低，胚胎/胎儿毒性（包括致畸性）和后代生长减少。本文综述了铀的生殖毒性，母体毒性，胚胎/胎儿毒性和产后效应，以及螯合剂对铀诱导的母体和发育毒性的预防作用。还审查了关于贫铀对生殖和发育的毒性作用的数据。

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