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首页> 外文期刊>Reproductive toxicology >Two-generation reproduction studies in Rats fed di-isodecyl phthalate.
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Two-generation reproduction studies in Rats fed di-isodecyl phthalate.

机译：饲喂邻苯二甲酸二异癸酯的大鼠的两代生殖研究。

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摘要

Di-isodecyl phthalate (DIDP) is a commercial plasticizer with low toxicity in many animal studies. The effects of dietary DIDP administration on fertility and developmental parameters were assessed in Sprague-Dawley rats utilizing two generation reproductive toxicity studies generally consistent with current regulatory guidelines. Dietary levels ranged from 0.02 to 0.8% (or approximately 15 to 600 mg/kg/day). In the reproductive studies, there were no effects on fertility, but there were decreases in adult body weight along with corresponding increases in liver and kidney weights and histopathologic changes indicative of peroxisomal proliferation. There were no effects on live birth index, but reduced offspring survival was observed at postnatal days 1 to 4. This reduced survival was more pronounced in the F2 generation in which statistical significance was achieved at levels of 0.2% DIDP and greater. There were also transient decreases in offspring body weights prior to weaning, corresponding to rapid offspring growth, and high levels of food consumption. There were no notable alterations in developmental landmarks. Overall, these studies provided experimentally defined No-Observed-Adverse-Effect Levels (NOAELs) of 0.06% (approximately 50 mg/kg/day) for F2 offspring survival and 0.8% (approximately 600 mg/kg/day) for fertility, other measures of reproductive function, and developmental landmarks. Statistical evaluation of the data from both studies identified 108 mg/kg/day with a 95% lower bound value of 86 mg/kg/day as a theoretical NOAEL for reduced F2 offspring survival.
机译：在许多动物研究中，邻苯二甲酸二异癸酯（DIDP）是一种毒性低的商业增塑剂。在Sprague-Dawley大鼠中，通过两代生殖毒性研究，评估了饮食中DIDP施用对生育能力和发育参数的影响，这些研究通常与当前的监管指南相一致。饮食水平为0.02％至0.8％（或约15至600 mg / kg /天）。在生殖研究中，对生育力没有影响，但成人体重有所减少，肝脏和肾脏的重量也相应增加，表明过氧化物酶体增生的组织病理学改变。对活产指数没有影响，但是在出生后的第1至4天观察到后代存活率降低。在F2代中存活率降低更为明显，在F2代中DIDP含量为0.2％或更高时，具有统计学意义。断奶前后代的体重也有短暂的下降，这对应于后代的快速生长和高水平的食物消耗。发展里程碑没有明显变化。总体而言，这些研究为F2后代存活提供了0.06％（约50 mg / kg /天）的无观察不良作用水平（NOAEL），为生育力提供了0.8％（约600 mg / kg /天）的无观察不良作用水平（其他）生殖功能和发展标志性指标。两项研究数据的统计评估结果均显示108 mg / kg /天和95％下限值为86 mg / kg /天，这是降低F2后代存活率的理论NOAEL。

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