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首页> 外文期刊>Reproductive toxicology >Developmental toxicity of di-(C(7)-C(9) alkyl) phthalate and di-(C(9)-C(11) alkyl) phthalate in the rat.
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Developmental toxicity of di-(C(7)-C(9) alkyl) phthalate and di-(C(9)-C(11) alkyl) phthalate in the rat.

机译：邻苯二甲酸二-（C（7）-C（9）烷基）和邻苯二甲酸二-（C（9）-C（11）烷基）的发育毒性。

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Two phthalate esters, di-(C(7)-C(9) alkyl) phthalate (D79P) and di-(C(9)-C(11) alkyl) phthalate (D911P), have been assessed for their potential to cause developmental toxicity in the rat. Groups of 22 timed-mated Sprague-Dawley rats were administered 250, 500, or 1000 mg/kg D79P or D911P daily by oral gavage (5 ml/kg) between gestation days (GD) 1 and 19. Control animals received the vehicle (olive oil) alone. On GD20, the animals were sacrificed and the fetuses examined. Treatment resulted in no signs of maternal toxicity, as assessed by adjusted maternal bodyweight gain throughout gestation and clinical examinations, and no effects upon litter size, fetal survival or bodyweight. Pups of the high dose D79P and intermediate and high dose D911P groups showed increased incidences of supernumerary lumbar ribs. There was a significant increase in dilated renal pelves in pups of the low dose D79P and high dose D911P groups, but only for D911P was there a significant trend. Consequently, the no observed adverse effect level (NOAEL) for maternal toxicity for both D79P and D911P is 1000 mg/kg/day. The NOAEL values for developmental toxicity are 500 mg/kg/day D79P and 250 mg/kg/day D911P.
机译：已评估了两种邻苯二甲酸酯邻苯二甲酸二（C（7）-C（9）烷基）（D79P）和邻苯二甲酸二（C（9）-C（11）烷基）（D911P）的潜在可能性大鼠发育毒性。在妊娠第1天和第19天之间，通过口服强饲法（5 ml / kg），每天对250只，500 mg / kg D79P或D911P / D911P组的22只定时交配的Sprague-Dawley大鼠进行分组。对照动物接受了赋形剂（橄榄油）。在GD20上，处死动物并检查胎儿。通过在整个妊娠和临床检查中调整孕妇的体重来评估，治疗没有导致孕妇毒性的迹象，并且对产仔数，胎儿存活率或体重没有影响。高剂量D79P和中，高剂量D911P组的幼犬显示出多余的腰椎肋骨发生率增加。低剂量D79P和高剂量D911P组的幼犬的肾盂扩张明显，但仅D911P有明显的趋势。因此，未观察到的D79P和D911P对母体毒性的不良反应水平（NOAEL）为1000 mg / kg /天。发育毒性的NOAEL值是500 mg / kg /天D79P和250 mg / kg /天D911P。

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