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首页> 外文期刊>Reproductive toxicology >Increased susceptibility to retinoid-induced teratogenesis in TGF-beta2 knockout mice.
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Increased susceptibility to retinoid-induced teratogenesis in TGF-beta2 knockout mice.

机译：TGF-beta2基因敲除小鼠对类维生素A致畸形成的敏感性增加。

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Transforming growth factor-beta (TGF-beta) and retinoic acid (RA) have been implicated in normal and abnormal embryonic development. The aim of this study was to investigate the effect of TGF-beta2 gene deletion on susceptibility to RA-induced teratogenesis in a mouse model. TGF-beta2 heterozygous or wild-type mice were mated and the dams dosed with a teratogenic dose of RA, or with control vehicle. The incidence of RA-induced cleft palate (CP) was 48% in wild-type embryos from wild-type dams, increasing to 71% in TGF-beta2 heterozygous littermates. Wild-type and TGF-beta2 heterozygous embryos from heterozygous dams exhibited a CP incidence of 74 and 77% respectively, following treatment with RA. Ninety-one percent of littermates nullizygous for TGF-beta2 were dead when examined; the remainder exhibited a CP. We conclude that the genotype of the dam and embryo with respect to TGF-beta2 affects the incidence of RA-induced teratogenesis.
机译：转化生长因子-β（TGF-β）和视黄酸（RA）与正常和异常的胚胎发育有关。这项研究的目的是研究小鼠模型中TGF-β2基因缺失对RA致畸形成的敏感性。将TGF-beta2杂合或野生型小鼠交配，并给母鼠添加致畸剂量的RA或对照媒介。 RA诱导的pa裂（CP）的发生率在野生型大坝的野生型胚胎中为48％，在TGF-beta2杂合子同窝仔中增加到71％​​。用RA处理后，来自杂合坝的野生型和TGF-β2杂合子胚胎的CP发生率分别为74％和77％。 TGF-beta2无效的同窝仔中有91％死亡。其余的表现出CP。我们得出的结论是，相对于TGF-β2，大坝和胚胎的基因型影响RA致畸形成的发生率。

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