• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reproductive toxicology >Effects of in utero linuron exposure on rat Wolffian duct development.
【24h】

Effects of in utero linuron exposure on rat Wolffian duct development.

机译：宫内亚麻嘧啶暴露对大鼠沃尔夫菲管发育的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Linuron is an herbicide that displays weak androgen receptor antagonist activity. Male offspring exposed in utero to 50 mg/kg/day linuron often exhibit malformations in Wolffian duct derivatives (i.e. the epididymis and vas deferens). The objectives of this study were to determine the point during the perinatal period that linuron-induced epididymal lesions can be identified, to characterize linuron-mediated perinatal testicular and epididymal pathology, and to determine whether male rat fetuses exposed prenatally to linuron exhibit decreased intratesticular and serum testosterone (T) levels. Pregnant rats were administered corn oil vehicle or linuron by gavage at 0 or 50 mg/kg/day (n = 3 controls, 5-11 linuron-treated dams per time point) from gestation days (GD) 12 to 21 or to termination. Male fetuses or offspring were necropsied on GD 17, 19, and 21, and postnatal days (PND) 7 and 14. Epididymal malformations were not observed in fetuses from linuron-treated dams but were seen in linuron-exposed male offspring on PND 7 and 14. No testicular lesions were observed at any time point. The growth and development of linuron-exposed fetuses were altered, as evidenced by slight decreases in fetal weight and increased levels of immunoreactive proliferating cell nuclear antigen (PCNA) on GD 21. Intratesticular and serum T levels were not decreased in linuron-exposed male fetuses. These findings indicate that the adversely altered adult phenotype following in utero exposure to linuron is very similar to that produced by the antiandrogens di-n-butyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP). However, the absence of testicular lesions or alterations in fetal testosterone levels would suggest that the effect of linuron on the developing Wolffian ducts is distinctly different from DBP or DEHP.
机译：Linuron是一种显示弱雄激素受体拮抗剂活性的除草剂。在子宫内暴露于50 mg / kg / day linuron的雄性后代通常表现出Wolffian导管衍生物（即附睾和输精管）畸形。这项研究的目的是确定围产期可识别出由利尿隆引起的附睾病变的点，以表征由利尿隆介导的围产期睾丸和附睾的病理特征，并确定产前暴露于利尿隆的雄性大鼠胎儿是否表现出睾丸内和睾丸内分泌减少。血清睾丸激素（T）水平。从妊娠天（GD）第12天到21天或终止妊娠，以0或50 mg / kg /天（n = 3个对照组，每个时间点5-11个利尿隆处理的大坝）通过管饲法给怀孕的大鼠施用玉米油赋形剂或利奴隆。在GD 17、19和21以及出生后第7天和第14天对男性胎儿或后代进行了尸检。在用linuron处理的大坝的胎儿中未观察到附睾畸形，但在PND 7和PN暴露于利尿隆的雄性后代中观察到附睾畸形。 14.在任何时间点均未观察到睾丸病变。 GD 21的胎儿体重轻度下降和免疫反应性增殖细胞核抗原（PCNA）水平升高，证明了暴露于利尿龙的胎儿的生长和发育发生了改变。 。这些发现表明，在子宫内暴露于亚麻嘧啶后，不良的成年表型与抗雄激素邻苯二甲酸二正丁酯（DBP）和邻苯二甲酸二（2-乙基己基）酯（DEHP）产生的表型非常相似。但是，如果没有睾丸病变或胎儿睾丸激素水平发生变化，则表明利尿灵对正在发育的沃尔夫导管的作用与DBP或DEHP明显不同。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号