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首页> 外文期刊>Reproductive toxicology >Alteration of pregnancy related hormones and fetal survival in F-344 rats exposed by inhalation to benzo(a)pyrene.
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Alteration of pregnancy related hormones and fetal survival in F-344 rats exposed by inhalation to benzo(a)pyrene.

机译：吸入苯并（a）exposed暴露的F-344大鼠的妊娠相关激素和胎儿存活率的变化。

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The objective of this study was to evaluate the effect of subacute exposure to inhaled benzo(a)pyrene (BaP) on fetal survival and luteal maintenance using timed-pregnant Fisher 344 rats. Prior to assignment of pregnant rats to treatment and control groups, numbers of implantation sites were determined on gestation day (GD) 8 via midventral laparotomy. Subsequently, animals were assigned randomly to three treatment groups and two control groups. Treatment consisted of subacute exposure of rats via inhalation to BaP 25, 75, and 100 micro g/m(3), 4h daily for 10 days (GD-11-20). Control animals were either sham exposed to carbon black (CB) to control for inert BaP carrier or remained unexposed (UNC). Blood samples were collected on days 15 and 17 of gestation via sinus orbital veini-puncture for plasma. Number of pups per litter was determined postpartum and fetal survival rate was expressed as a percentage of the corresponding implantation sites. Radioimmunoassays were used to determine plasma progesterone, estrogen, and prolactin (indirect measurement of decidual luteotropin) concentrations. Fetal survival among BaP-treated rats declined in a dose-dependent manner (25 micro g/m(3), 78.3% per litter; 75 micro g/m(3), 38.0% per litter; 100 micro g/m(3), 33.8% per litter; P<0.05) compared with CB (96.7% per litter) and UNC (98.9% per litter). Plasma progesterone, estrogen, and prolactin concentrations also declined as a result of subacute exposure of rats to BaP compared to controls. These data suggest that inhaled BaP compromised fetal survival and consequently luteotropic activity in the exposed animals.
机译：这项研究的目的是评估使用定时妊娠的Fisher 344大鼠亚急性暴露于吸入的苯并（a）re（BaP）对胎儿存活和黄体维持的影响。在将妊娠大鼠分为治疗组和对照组之前，通过腹中腹剖腹术在妊娠第8天确定植入部位的数量。随后，将动物随机分为三个治疗组和两个对照组。治疗包括大鼠通过吸入BaP 25、75和100 micro g / m（3）亚急性暴露，每天4h，共10天（GD-11-20）。对照动物或者假暴露于炭黑（CB）以控制惰性BaP载体，或者保持不暴露（UNC）。在妊娠的第15天和第17天通过窦眼眶静脉穿刺采集血样以获取血浆。确定产后每窝幼崽的数量，并将胎儿存活率表示为相应植入位点的百分比。放射免疫测定法可用于测定血浆孕酮，雌激素和催乳激素（蜕膜性促肾上腺皮质激素的间接测定）浓度。 BaP处理的大鼠中的胎儿存活率呈剂量依赖性下降（25 micro g / m（3），每窝78.3％; 75 micro g / m（3），38.0％每窝; 100 micro g / m（3 ），每窝33.8％; P <0.05），而CB（每窝96.7％）和UNC（每窝98.9％）。与对照组相比，由于大鼠亚急性暴露于BaP，血浆孕酮，雌激素和催乳激素的浓度也降低了。这些数据表明，在暴露的动物中，吸入的BaP损害了胎儿的存活率，并因此破坏了嗜黄性。

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