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首页> 外文期刊>Reproductive toxicology >Assessing combined chemical exposures as risk factors for neural tube defects(1).
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Assessing combined chemical exposures as risk factors for neural tube defects(1).

机译：将综合化学暴露评估为神经管缺陷的危险因素（1）。

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Many studies have investigated whether chemical exposures early in pregnancy increase risks to women of delivering offspring with congenital anomalies. We investigated whether periconceptional exposures to chemicals in combination increased risks to women of having neural tube defect (NTD)-affected pregnancies. Women were asked about occupational tasks performed during the periconceptional period. These tasks were assigned by an industrial hygienist to a priori defined exposure categories. The exposure categories included 74 chemical groups. Two population-based case control studies were analyzed. Information on tasks was obtained from mothers of 538 NTD cases and their 539 controls in one study, and mothers of 265 NTD cases and 481 controls from another study. We used data from the first study to identify clues. Specifically, we estimated NTD risks for maternal occupational exposures to all possible pairs, triplets, and quadruplets of 74 chemical groups. Chemical combinations revealing elevated NTD risks in these "clue generation" analyses were then investigated in the second population-based case-control study for their contribution to risk of NTDs. We computed odds ratios for each of the total 192,374 possible comparisons and identified all combinations that produced odds ratios of 5 or more. A 5-fold elevated risk criterion revealed 53 combinations. These 53 reflected various combinations of exposures exclusive to 12 of 74 chemical groups. Analyses of data from the second study did not identify odds ratios of 2.0 or greater for maternal exposures to the 12 chemical groups that resulted in 5-fold elevated risks in the first study. Despite the use of a labor-intensive method to categorize exposures, we were unable to substantiate clues associated with combined chemical exposures identified in one large case-control study as NTD risk factors in a second case-control study.
机译：许多研究调查了怀孕初期的化学暴露是否会增加分娩先天性异常的妇女的风险。我们调查了围生期接触化学药品是否会增加受神经管缺陷（NTD）影响的孕妇的风险。询问妇女在围孕期执行的职业任务。工业卫生员将这些任务分配给事先定义的暴露类别。暴露类别包括74个化学类别。分析了两个基于人群的病例对照研究。在一项研究中，有关任务的信息来自538名NTD病例的母亲及其539名对照，而另一项研究则由265名NTD病例的母亲和481名对照获得。我们使用第一项研究的数据来确定线索。具体而言，我们估算了74种化学组的所有可能对，三联体和四联体的孕产妇职业接触NTD风险。然后，在第二项基于人群的病例对照研究中，对在这些“线索产生”分析中揭示NTD风险升高的化学组合进行了研究，探讨它们对NTD风险的贡献。我们为总共192,374个可能的比较中的每一个计算了比值比，并确定了产生5或更高的比值比的所有组合。高风险标准的5倍揭示了53种组合。这53个反映了74种化学组中的12种独有的各种暴露组合。第二项研究的数据分析未发现孕妇暴露于12个化学组的比值比为2.0或更高，从而导致第一项研究中的风险增加了5倍。尽管使用了劳动强度大的方法对暴露进行分类，但我们无法证实与另一项大型病例对照研究中确定为NTD危险因素的联合化学暴露相关的线索。

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