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首页> 外文期刊>Reproductive toxicology >Low-dose bisphenol A does not affect reproductive organs in estrogen-sensitive C57BL/6N mice exposed at the sexually mature, juvenile, or embryonic stage.
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Low-dose bisphenol A does not affect reproductive organs in estrogen-sensitive C57BL/6N mice exposed at the sexually mature, juvenile, or embryonic stage.

机译：在性成熟，幼年或胚胎阶段暴露的雌激素敏感性C57BL / 6N小鼠中，低剂量双酚A不会影响生殖器官。

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Bisphenol A (BPA) is used on a large scale in the manufacture of polycarbonate plastics. BPA has been shown to bind weakly to both estrogen receptor (ER) alpha and ER beta. The objective of this study was to evaluate the effects of low-dose BPA on male sexual development after exposure at various stages of development. Mice of the estrogen-sensitive strain C57BL/6N were exposed to BPA orally at doses of 2, 20, or 200 microg/kg at various stages, i.e. adulthood, the immature stage just after weaning, or the embryonic/fetal stage, to evaluate the effects of low-dose BPA on male reproductive organs. Body weight changes, weights of reproductive organs (testes, epididymides, seminal vesicles), cauda epididymal sperm density, and histology of reproductive organs including the ventral prostate were not affected by exposure to BPA at any dose examined. The results of this study indicate that exposure of estrogen-sensitive C57BL/6N mice to low-dose BPA did not reduce sperm density or disrupt development of the male reproductive organs.
机译：双酚A（BPA）在聚碳酸酯塑料的生产中被大量使用。 BPA已显示与雌激素受体（ER）α和ERβ均弱结合。这项研究的目的是评估低剂量BPA在不同发育阶段暴露后对男性性发育的影响。将雌激素敏感性菌株C57BL / 6N的小鼠在成年，断奶后不成熟或胚胎/胎儿期等各个阶段以2、20或200 microg / kg的剂量口服BPA进行评估低剂量双酚A对男性生殖器官的影响。体重变化，生殖器官（睾丸，附睾，精囊）的重量，附睾马尾附睾精子密度以及生殖器官的组织学（包括腹侧前列腺）均不受BPA暴露量的影响。这项研究的结果表明，雌激素敏感性C57BL / 6N小鼠暴露于低剂量BPA不会降低精子密度或破坏雄性生殖器官的发育。

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