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首页> 外文期刊>Cell transplantation >The role of alloresponsive Ly49+ NK cells in rat islet allograft failure in the presence and absence of cytomegalovirus
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The role of alloresponsive Ly49+ NK cells in rat islet allograft failure in the presence and absence of cytomegalovirus

机译：在存在和不存在巨细胞病毒的情况下，同种反应性Ly49 + NK细胞在大鼠胰岛同种异体移植失败中的作用

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There are still many factors to discover to explain the low success rates of islet allografts. In this study, we demonstrate that specific subpopulations of alloreactive NK cells may be involved in the failure of islet allografts. By performing allotransplantation in rats (n?=?13), we observed peripheral expansion and infiltration of alloreactive Ly49i2+ NK cells in the grafts. An effective strategy in rats to enhance the expansion of Ly49i2+ NK cells is performing a rat cytomegalovirus infection (n?=?6). Cytomegalovirus infection was associated with an early expansion of the Ly49i2+ NK cells and accelerated islet graft failure. The Ly49i2+ NK cells are both alloreactive and involved in virus clearance. The expansion of this subpopulation could not be blocked by cyclosporin A immunosuppression. Also alloreactive KLRH1+ NK cells infiltrated the grafts, but nonalloreactive NKR-P1B+ cells were not observed in the islet allografts. Perforin staining of the infiltrating NK cells demonstrated the cytotoxic capacity of these cells. Our data suggest a role for this NK subpopulation in rat islet allograft destruction.
机译：仍有许多因素可以用来解释胰岛同种异体移植成功率低的原因。在这项研究中，我们证明了同种异体反应性NK细胞的特定亚群可能与胰岛同种异体移植的失败有关。通过在大鼠中进行同种异体移植（n = 13），我们观察到移植物中同种反应性Ly49i2 + NK细胞的外周扩张和浸润。在大鼠中增强Ly49i2 + NK细胞扩增的有效策略是进行大鼠巨细胞病毒感染（n≥6）。巨细胞病毒感染与Ly49i2 + NK细胞的早期扩增和加速的胰岛移植失败有关。 Ly49i2 + NK细胞具有同种反应性并参与病毒清除。该亚群的扩增不能被环孢菌素A的免疫抑制所阻断。同样，同种异体反应性KLRH1 + NK细胞也浸润了移植物，但是在胰岛同种异体移植物中未观察到非同种异性反应性NKR-P1B +细胞。渗透性NK细胞的穿孔素染色证明了这些细胞的细胞毒性能力。我们的数据表明该NK亚群在大鼠胰岛同种异体移植破坏中的作用。

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