...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reproductive toxicology >Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb.
【24h】

Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb.

机译：新生儿接触双酚A或己烯雌酚会改变羔羊的卵巢卵泡动力学。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We hypothesized that neonatal xenoestrogen exposure affects the ovarian follicular dynamics in lambs. Female lambs were exposed from postnatal day (PND) 1-14 to low doses of diethylstilbestrol (DES) or bisphenol A (BPA). At PND 30, the follicular dynamics and ovarian biomarkers (ERalpha, ERbeta, AR, Ki67, p27) were evaluated. Lambs exposed to DES or BPA showed a decline in the stock of primordial follicles with stimulation of follicular development. BPA reduced ovarian weight and increased the number of multioocyte follicles. BPA promoted proliferation of granulosa/theca cells in antral follicles, and increased both the number of antral atretic follicles and p27 expression. Neonatal exposure to BPA or DES reduced the primordial follicle pool by stimulating their initial recruitment and subsequent follicle development until antral stage. In prepubertal lambs, the accelerated folliculogenesis resulted in increased incidence of atretic follicles. These alterations may affect the ovarian function in the adult.
机译：我们假设新生儿异种雌激素的暴露会影响羔羊的卵巢卵泡动力学。从产后一天（PND）1-14日开始，将雌性小羊暴露于低剂量的己烯雌酚（DES）或双酚A（BPA）中。在PND 30处，评估了卵泡动力学和卵巢生物标记（ERalpha，ERbeta，AR，Ki67，p27）。暴露于DES或BPA的羔羊显示原始卵泡的存量下降，并刺激卵泡发育。 BPA减少了卵巢重量，并增加了多卵泡的卵泡数量。 BPA促进了窦性卵泡中颗粒细胞/卵泡膜细胞的增殖，并增加了胃窦性卵泡的数量和p27的表达。新生儿接触BPA或DES可以刺激原始募集和随后的卵泡发育直至肛门期，从而减少了原始卵泡池。在青春期前的羔羊中，加速的卵泡生成导致闭锁卵泡的发生率增加。这些改变可能会影响成年人的卵巢功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号