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首页> 外文期刊>Reproductive toxicology >Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver.
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Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver.

机译：口服甲基叔丁基醚（MTBE）对雄性小鼠生殖道和肝脏氧化应激的影响。

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摘要

MTBE is found in water supplies used for drinking and other purposes. These experiments follow up on earlier reports of reproductive tract alterations in male mice exposed orally to MTBE and explored oxidative stress as a mode of action. CD-1 mice were gavaged with 400-2000 mg/kg MTBE on days 1, 3, and 5, injected i.p. with hCG (2.5 IU/g) on day 6, and necropsied on day 7. No effect was seen in testis histology or testosterone levels. Using a similar dosing protocol, others had initially reported disruption of seminiferous tubules in MTBE-gavaged mice, although later conclusions published were consistent with our findings. Another group had also reported testicular and other reproductive system abnormalities in male BALB/c mice exposed for 28 days to 80-8000 microg/ml MTBE in drinking water. We gave these MTBE concentrations to adult mice for 28 days and juvenile mice for 51 days through PND 77. Evidence of oxidative stress was examined in liver homogenates from the juvenile study using MDA, TEAC and 8OH2hG as endpoints. MTBE exposures at the levels examined indicated no significant changes in the male mouse reproductive tract and no signs of hepatic oxidative stress. This appears to be the first oral MTBE exposure of juvenile animals, and also the first to examine potential for MTBE to cause oxidative stress in vivo using a typical route of human exposure.
机译：MTBE存在于用于饮用水和其他目的的供水中。这些实验是对口服MTBE的雄性小鼠生殖道改变的早期报道进行的后续研究，并探讨了氧化应激作为一种作用方式。在第1、3和5天腹腔注射400-2000 mg / kg MTBE对CD-1小鼠进行灌胃。在第6天使用hCG（2.5 IU / g），第7天进行尸检。睾丸组织学或睾丸激素水平未见影响。使用类似的剂量方案，其他人最初报道了MTBE感染小鼠的曲细精管破裂，尽管后来发表的结论与我们的发现一致。另一组也报告了雄性BALB / c小鼠在饮用水中暴露于80-8000 microg / ml MTBE 28天后的睾丸和其他生殖系统异常。我们通过PND 77将这些MTBE浓度分别提供给成年小鼠28天和未成年小鼠51天。使用MDA，TEAC和8OH2hG作为终点，从青少年研究的肝匀浆中检查了氧化应激的证据。在所检测水平的MTBE暴露量表明，雄性小鼠生殖道没有明显变化，也没有肝氧化应激的迹象。这似乎是幼年动物第一次口服MTBE暴露，也是首次使用典型的人类暴露途径研究MTBE在体内引起氧化应激的潜力。

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