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首页> 外文期刊>Reproductive toxicology >Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure.
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Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure.

机译：甲基汞在经历神经管闭合的C57和SWV小鼠胚胎中诱导了毒理基因组反应。

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摘要

Methylmercury (MeHg) is a developmental neurotoxicant and teratogen and is hypothesized to perturb a wide range of biological processes, like other metals including arsenic (As) and cadmium (Cd). Common inbred mouse strains including C57 (sensitive) and SWV (resistant) display differences in sensitivity to metals such as As and Cd when exposed during neurulation. In this study, we investigated the impact of MeHg on neurulation, assessing for potential differences in sensitivity and associated toxicogenomic response in C57 and SWV mouse embryos. Parallel with morphological assessments of neural tube closure, we evaluated quantitative differences in MeHg-induced alterations in expression between strains at the gene level and within gene-enriched biological processes. Specifically, we observed differing sensitivities to MeHg-induced impacts on neural tube closure between C57 and SWV embryos in a time-dependent manner. These observations correlated with greater impact on the expression of genes associated with development and environmental stress-related pathways in the C57 compared to the SWV. Additional developmental parameters (e.g. mortality, growth effects) evaluated showed mixed significant effects across the two strains and did not support observations of differential sensitivity to MeHg. This study provides potential insights into MeHg-induced mechanisms of developmental toxicity, alterations associated with increased MeHg sensitivity and common biological processes affected by metals in embryos undergoing neurulation.
机译：甲基汞（MeHg）是一种发育性神经毒剂和致畸剂，据推测会扰乱广泛的生物过程，就像其他金属，包括砷（As）和镉（Cd）。常见的近交小鼠品系，包括C57（敏感）和SWV（抗性），在培养过程中暴露时对金属（例如As和Cd）的敏感性差异。在这项研究中，我们调查了甲基汞对神经元的影响，评估了C57和SWV小鼠胚胎的敏感性和相关的毒理基因组反应的潜在差异。与神经管闭合的形态学评估并行，我们在基因水平和基因富集的生物学过程中评估了菌株之间MeHg诱导表达变化的定量差异。具体来说，我们观察到对MeHg诱导的对C57和SWV胚胎之间神经管闭合的影响的敏感性呈时间依赖性。与SWV相比，这些观察结果与C57中与发育和环境胁迫相关途径相关的基因表达的影响更大有关。评估的其他发育参数（例如死亡率，生长效应）显示了两种菌株之间混合的显着效应，并且不支持观察到对MeHg的敏感性差异。这项研究提供了潜在的见解，以了解甲基汞诱导的发育毒性机制，与甲基汞敏感性增加相关的改变以及受胚胎培养的金属影响的常见生物过程。

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