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首页> 外文期刊>Reproductive toxicology >Neonatal diethylstilbestrol exposure disrupts female reproductive tract structure/function via both direct and indirect mechanisms in the hamster.
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Neonatal diethylstilbestrol exposure disrupts female reproductive tract structure/function via both direct and indirect mechanisms in the hamster.

机译：新生儿己烯雌酚的暴露通过仓鼠中的直接和间接机制破坏了女性生殖道的结构/功能。

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摘要

We assessed neonatal diethylstilbestrol (DES)-induced disruption at various endocrine levels in the hamster. In particular, we used organ transplantation into the hamster cheek pouch to determine whether abnormalities observed in the post-pubertal ovary are due to: (a) a direct (early) mechanism or (b) an indirect (late) mechanism that involves altered development and function of the hypothalamus and/or pituitary. Of the various disruption endpoints and attributes assessed: (1) some were consistent with the direct mechanism (altered uterine and cervical dimensions/organization, ovarian polyovular follicles, vaginal hypospadius, endometrial hyperplasia/dysplasia); (2) some were consistent with the indirect mechanism (ovarian/oviductal salpingitis, cystic ovarian follicles); (3) some were consistent with a combination of the direct and indirect mechanisms (altered endocrine status); and (4) the mechanism(s) for one (lack of corpora lutea) was uncertain. This study also generated some surprising observations regarding vaginal estrous assessments as a means to monitor periodicity of ovarian function in the hamster.
机译：我们评估了仓鼠中各种内分泌水平下的新生儿己烯雌酚（DES）诱导的破坏。特别是，我们使用器官移植到仓鼠脸颊袋中来确定在青春期后卵巢中观察到的异常是否是由于：（a）直接（早期）机制或（b）涉及发育改变的间接（晚期）机制引起的下丘脑和/或垂体的功能。在评估的各种破坏终点和属性中：（1）一些与直接机制一致（子宫和宫颈尺寸/组织改变，卵巢多卵泡卵泡，阴道下垂，子宫内膜增生/异型增生）; （2）某些与间接机制一致（卵巢/输卵管输卵管炎，卵巢囊性卵泡）; （3）有些与直接和间接机制相结合（内分泌状态改变）; （4）一种（缺乏黄体）的机制尚不确定。这项研究还产生了一些关于阴道发情评估的令人惊讶的观察结果，作为监测仓鼠卵巢功能周期性的一种手段。

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