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首页> 外文期刊>Reproductive toxicology >Effects of 4-tert-octylphenol on the testes and seminal vesicles in adult male bank voles.
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Effects of 4-tert-octylphenol on the testes and seminal vesicles in adult male bank voles.

机译：4-叔辛基苯酚对成年雄性河岸田鼠睾丸和精囊的影响。

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摘要

The present study was designed to evaluate the effects of 4-tert-octylphenol (OP) on male testes and seminal vesicles of bank vole. Adult males kept under long or short photoperiod were orally administered OP (200mg/kg bw) for 30 or 60 days. Treatment for 30 days had no discernible effect on the parameters examined. Treatment for 60 days adversely influenced weights and histological structure of the testes and seminal vesicles. In these tissues, expression of 3beta-hydroxysteroid dehydrogenase and androgen receptor and testosterone levels were reduced, whereas expression of aromatase and estrogen receptor alpha and estradiol levels were increased. The alterations were more evident in voles kept in long photoperiod. Taken together, it is suggested that adverse changes in bank vole reproductive tissues induced by long-term OP-exposure result from disturbed androgen and estrogen synthesis and action. Moreover, there might be a subtle difference in the sensitivity to OP between voles kept in different light conditions.
机译：本研究旨在评估4-叔辛基苯酚（OP）对岸田鼠雄性睾丸和精囊的影响。长期或短期处于光周期的成年雄性，口服给予OP（200mg / kg bw）30或60天。 30天的治疗对所检查的参数无明显影响。 60天的治疗会对睾丸和精囊的重量和组织学结构产生不利影响。在这些组织中，3β-羟类固醇脱氢酶和雄激素受体和睾丸激素的表达降低，而芳香化酶和雌激素受体α和雌二醇的表达增加。这种变化在长期处于光周期的田鼠中更为明显。两者合计，建议长期OP暴露引起的岸田鼠生殖组织的不利变化是由雄激素和雌激素的合成和作用受阻引起的。此外，在不同光照条件下饲养的田鼠对OP的敏感性可能存在细微差异。

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