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Zebrafish developmental screening of the ToxCast? Phase I chemical library

机译：斑马鱼的ToxCast发育筛查？一期化学库

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摘要

Zebrafish (Danio rerio) is an emerging toxicity screening model for both human health and ecology. As part of the Computational Toxicology Research Program of the U.S. EPA, the toxicity of the 309 ToxCast? Phase I chemicals was assessed using a zebrafish screen for developmental toxicity. All exposures were by immersion from 6-8. h post fertilization (hpf) to 5 days post fertilization (dpf); nominal concentration range of 1. nM-80. μM. On 6. dpf larvae were assessed for death and overt structural defects. Results revealed that the majority (62%) of chemicals were toxic to the developing zebrafish; both toxicity incidence and potency was correlated with chemical class and hydrophobicity (logP); and inter-and intra-plate replicates showed good agreement. The zebrafish embryo screen, by providing an integrated model of the developing vertebrate, compliments the ToxCast assay portfolio and has the potential to provide information relative to overt and organismal toxicity.
机译：斑马鱼（Danio rerio）是一种针对人类健康和生态学的新兴毒性筛选模型。作为美国EPA计算毒理学研究计划的一部分，309 ToxCast？的毒性如何？使用斑马鱼筛选评估了I期化学品的发育毒性。所有曝光都是通过浸入6-8进行的。受精后h（hpf）至受精后5天（dpf）;标称浓度范围为1. nM-80。微米在6月，评估dpf幼虫的死亡和明显的结构缺陷。结果表明，大多数化学药品（62％）对发育中的斑马鱼有毒;毒性发生率和效力均与化学类别和疏水性（logP）相关;板间和板内重复显示出良好的一致性。斑马鱼胚胎筛查通过提供发育中脊椎动物的集成模型，补充了ToxCast分析产品组合，并具有提供有关公开和生物毒性的信息的潜力。

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