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首页> 外文期刊>Reproductive toxicology >Is embryo-cryopreservation really neutral?; A new long-term effect of embryo freezing in mice: protection of adults from induced cancer according to strain and sex.
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Is embryo-cryopreservation really neutral?; A new long-term effect of embryo freezing in mice: protection of adults from induced cancer according to strain and sex.

机译：胚胎冷冻保存真的是中性的吗？小鼠胚胎冷冻的一种新的长期作用：根据品系和性别保护成年人免于诱发癌症。

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Background: Beneficial or harmful effects of embryo freezing have been described in man and animals, raising the question of the neutrality of this technique. Objective: We examined, in mice, the possibility that embryo freezing influences the probability of the emergence, in adults, of an induced urinary bladder cancer. Methods: The experiment was conducted in mice derived from embryos of two different genotypes. Females receiving embryos were parsed into two groups according to whether these embryos were cryopreserved or not. The derived adults received the chemical carcinogen N-butyl-N-4hydroxybutylnitrosamine (BBN), in the drinking water. Time to death since the onset of treatment was measured for each animal until the 300th day. Results: In females from one of the two strains tested, embryo freezing led to a favorable long-term effect on the probability of resistance to induced cancer. Conclusion: This beneficial effect, taken together with other effects reported in the literature be they beneficial or harmful, suggests that embryo freezing in mice may not be neutral.
机译：背景：已经有人和动物描述了胚胎冷冻的有益或有害作用，这引发了该技术的中立性问题。目的：我们在小鼠中检查了胚胎冻结影响成人诱发的膀胱癌的可能性的可能性。方法：在源自两种不同基因型胚胎的小鼠中进行实验。根据是否将胚胎冷冻保存，将接受胚胎的雌性分为两组。衍生的成年人在饮用水中接受了化学致癌物N-丁基-N-4羟基丁基亚硝胺（BBN）。从每只动物直到第300天测量自治疗开始以来的死亡时间。结果：在来自所测试的两种菌株之一的雌性中，胚胎冷冻导致了对诱导性癌症的抵抗力的长期有利影响。结论：这种有益效果，再加上文献中报道的其他有益或有害效果，表明小鼠胚胎冷冻可能不是中性的。

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