...
首页> 外文期刊>Cellular Signalling >Cellular signaling and biological functions of R-spondins
【24h】

Cellular signaling and biological functions of R-spondins

机译:R-spondins的细胞信号传导和生物学功能

获取原文
获取原文并翻译 | 示例
           

摘要

R-spondins (RSPOs) are a family of cysteine-rich secreted proteins containing a single thrombospondin type I repeat (TSR) domain. A vast amount of information regarding cellular signaling and biological functions of RSPOs has emerged over the last several years, especially with respect to their roles in the activation of the WNT signaling pathway. The identification of several classes of RSPO receptors may indicate that this family of proteins can affect several signaling cascades. Herein, we summarize the current understanding of RSPO signaling and its biological functions, and discuss its potential therapeutic implications to human diseases.
机译:R-spondins(RSPOs)是富含半胱氨酸的分泌蛋白家族,包含单个I型重复血小板反应蛋白(TSR)域。在过去的几年中,已经出现了有关RSPO的细胞信号传导和生物学功能的大量信息,特别是关于它们在WNT信号通路激活中的作用方面。对几类RSPO受体的鉴定可能表明该蛋白家族可以影响几个信号级联。在此,我们总结了RSPO信号传导及其生物学功能的当前理解,并讨论了其对人类疾病的潜在治疗意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号