Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein

Sato K.; Handa H.; Kimura M.; Okano Y.; Nagaoka H.; Nagase T.; Sugiyama T.; Kitade Y.; Ueda H.

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Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein

机译：鉴定Rho家族特异性鸟嘌呤核苷酸交换因子FLJ00018作为一种新型肌动蛋白结合蛋白

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FLJ00018/PLEKHG2 is a guanine nucleotide exchange factor for the Rho family small GTPases. FLJ00018 is directly activated by heterotrimeric G protein Gβγ subunits. Using two-hybrid screening, we have identified non-muscle cytosolic actin as a binding partner of FLJ00018. We found that there were two actin-binding regions in FLJ00018 at the N-terminal region (150-283 amino acids) and at the C-terminal region (465-1386 amino acids). The overexpression of non-muscle cytosolic actin attenuated the FLJ00018-induced serum response element-dependent gene transcription. These results suggest that non-muscle cytosolic actin may be a negative regulator of FLJ00018 through its interaction with the Dbl homology domain.

机译：FLJ00018 / PLEKHG2是Rho家族小GTP酶的鸟嘌呤核苷酸交换因子。 FLJ00018被异源三聚体G蛋白Gβγ亚基直接激活。通过两次杂交筛选，我们确定了非肌肉胞质肌动蛋白是FLJ00018的结合伴侣。我们发现在FLJ00018的N端区域（150-283个氨基酸）和C端区域（465-1386个氨基酸）有两个肌动蛋白结合区。非肌肉胞质肌动蛋白的过表达减弱了FLJ00018诱导的血清反应元件依赖性基因转录。这些结果表明，非肌肉细胞质肌动蛋白可能通过其与Dbl同源域的相互作用而成为FLJ00018的负调节剂。

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《Cellular Signalling》 |2013年第1期|共9页
作者
Sato K.; Handa H.; Kimura M.; Okano Y.; Nagaoka H.; Nagase T.; Sugiyama T.; Kitade Y.; Ueda H.;
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正文语种 eng
中图分类细胞形态学;
关键词
Actin; FLJ00018; G protein; Gene transcription; Rho; RhoGEF;

机译：肌动蛋白;FLJ00018;G蛋白;基因转录;Rho;RhoGEF;

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1. Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein [J] . Sato K., Handa H., Kimura M., Cellular Signalling . 2013,第1期

机译：鉴定Rho家族特异性鸟嘌呤核苷酸交换因子FLJ00018作为一种新型肌动蛋白结合蛋白
2. Heterotrimeric G protein G alpha s subunit attenuates PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by direct interaction [J] . Sugiyama Kazue, Tago Kenji, Matsushita Sayumi, Cellular Signalling . 2017,第1期

机译：异映直甲蛋白Gαs亚基衰减Plekhg2，通过直接相互作用，rho家族特异性鸟嘌呤核苷酸交换因子
3. Gef10-the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture. [J] . Mohl M, Winkler S, Wieland T, Naunyn-Schmiedeberg's Archives of Pharmacology . 2006,第5期

机译：Gef10-具有异常蛋白质结构的Rho特异性鸟嘌呤核苷酸交换因子亚家族的第三个成员。
4. Functional Expression of Chemoreceptors with the Help of a Guanine Nucleotide Exchange Factor [C] . Bettina Malnic, Daniela C. Gonzalez-Kristeller International Symposium on Olfaction and Taste . 2009

机译：脱核蝶核苷酸交换因子的帮助下的化学感受器的功能表达
5. Specific recognition of Rho GTPases by DOCK180 family of guanine nucleotide exchange factors. [D] . Kwofie, Michael Akwantsin. 2006

机译：DOCK180鸟嘌呤核苷酸交换因子家族对Rho GTPases的特异性识别。
6. Threonine 680 Phosphorylation of FLJ00018/PLEKHG2 a Rho Family-specific Guanine Nucleotide Exchange Factor by Epidermal Growth Factor Receptor Signaling Regulates Cell Morphology of Neuro-2a Cells [O] . Katsuya Sato, Tsuyoshi Sugiyama, Takahiro Nagase, 2014

机译：表皮生长因子受体信号转导Rho家族特异性鸟嘌呤核苷酸交换因子FLJ00018 / PLEKHG2的苏氨酸680磷酸化调节神经2a细胞的细胞形态。
7. The Importance of Interaction with Membrane Lipids through the Pleckstrin Homology Domain of the Guanine Nucleotide Exchange Factor for Rho Family Small Guanosine Triphosphatase, FLJ00018 [O] . Shinji Kimura, Katsuya Sato, Yoshiko Banno, 2013

机译：通过Pleckstrin同源结构域的鸟嘌呤核苷酸交换因子与rho族核苷酸三磷酶，FLJ00018的鸟嘌呤核苷酸交换因子相互作用的重要性

Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein

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