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首页> 外文期刊>Cellular Signalling >Regulation of inflammation by extracellular acidification and proton-sensing GPCRs (Review)
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Regulation of inflammation by extracellular acidification and proton-sensing GPCRs (Review)

机译：通过细胞外酸化和质子感应GPCR调节炎症（综述）

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摘要

Under ischemic and inflammatory circumstances, such as allergic airway asthma, rheumatoid arthritis, atherosclerosis, and tumors, extracellular acidification occurs due to the stimulation of anaerobic glycolysis. An acidic microenvironment has been shown to modulate pro-inflammatory or anti-inflammatory responses, including cyclooxygenase-2 (COX-2) expression, prostaglandin synthesis, and cytokine expression, in a variety of cell types, and thereby to exacerbate or ameliorate inflammation. However, molecular mechanisms underlying extracellular acidic pH-induced actions have not been fully understood. Recent studies have shown that ovarian cancer G protein-coupled receptor 1 (OGR1)-family G protein-coupled receptors (GPCRs) can sense extracellular pH or protons, which in turn stimulates intracellular signaling pathways and subsequent diverse cellular responses. In the present review, I discuss extracellular acidic pH-induced inflammatory responses and related responses in inflammatory cells, such as macrophages and neutrophils, and non-inflammatory cells, such as smooth muscle cells and endothelial cells, focusing especially on proton-sensing GPCRs.
机译：在缺血和炎性情况下，例如过敏性气道哮喘，类风湿性关节炎，动脉粥样硬化和肿瘤，由于厌氧糖酵解的刺激，细胞外酸化发生。酸性微环境已显示可在多种细胞类型中调节促炎或抗炎反应，包括环氧合酶2（COX-2）表达，前列腺素合成和细胞因子表达，从而加剧或减轻炎症。但是，尚未完全了解细胞外酸性pH诱导作用的分子机制。最近的研究表明，卵巢癌G蛋白偶联受体1（OGR1）-家族G蛋白偶联受体（GPCR）可以感知细胞外pH或质子，进而刺激细胞内信号传导途径和随后的多种细胞反应。在本综述中，我讨论了胞外酸性pH诱导的炎症反应以及炎症细胞（例如巨噬细胞和嗜中性粒细胞）以及非炎症细胞（例如平滑肌细胞和内皮细胞）中的相关反应，特别是质子敏感的GPCR。

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