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首页> 外文期刊>Reproductive toxicology >Delayed reproductive dysfunction in female rats induced by early life exposure to low-dose diethylstilbestrol
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Delayed reproductive dysfunction in female rats induced by early life exposure to low-dose diethylstilbestrol

机译：早期暴露于低剂量己烯雌酚引起的雌性大鼠生殖功能延迟

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摘要

A one-lifespan test was carried out to establish a test protocol for endocrine-disrupting chemicals (EDCs). Diethylstilbestrol was administered by oral gavage to neonatal rats at doses of 0.05, 0.5 and 5 μg/kg/day for 5 days after birth. Abnormal estrous cycles were observed throughout the study in all females from the 5 μg/kg group, and in 40% from the 0.5 μg/kg group from 24 weeks of age. The conception rate of 12-week-old females in the 5 μg/kg group was 0%, and that of the 23-week-old females in the 0.5 μg/kg group was 33.3%. No effect of DES was observed at the first parturition in any group, except for the 5 μg/kg group. However, litter size was significantly reduced in the 0.5 μg/kg group at the second parturition. These results indicated that a prolonged period of observation of reproductive function is necessary to determine EDCs reliably.
机译：进行了一项全寿命测试，以建立干扰内分泌的化学物质（EDC）的测试方案。新生大鼠在出生后5天以0.05、0.5和5μg/ kg / day的剂量通过口管饲喂二乙基己烯雌酚。在整个研究中，从24周龄开始，在5μg/ kg组的所有女性中观察到异常的发情周期，而在0.5μg/ kg组的所有女性中观察到40％。 5μg/ kg组中12周龄女性的受孕率为0％，0.5μg/ kg组中23周龄女性的受孕率为33.3％。除5μg/ kg组外，任何组在第一次分娩时均未观察到DES的作用。但是，第二胎时，0.5μg/ kg组的产仔数显着减少。这些结果表明，必须长时间观察生殖功能才能可靠地确定EDC。

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