...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reproductive toxicology >Effects of acrylamide on rodent reproductive performance.
【24h】

Effects of acrylamide on rodent reproductive performance.

机译：丙烯酰胺对啮齿动物生殖性能的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acrylamide monomer causes peripheral neurotoxicity, mutagenicity, clastogenicity, male reproductive toxicity, prenatal lethality, and endocrine-related tumors in rodents. Acrylamide (and/or its metabolite glycidamide) binds to dopamine receptors and spermatid protamines and inhibits activity of kinesin and dyneine, resulting in interference with neuronal intracellular transport and sperm motility. Glycidamide binds to various proteins and DNA. Acrylamide at low doses decreases litter size, with rats more sensitive than mice. At higher doses, sperm morphology and motility and neurotoxicity are affected, which decreases mating frequency. Acrylamide does not affect female reproduction (females exhibit neurotoxicity). Dominant lethal mutations cause decreased newborn litter size. The mechanisms of action appear to be: (1) acrylamide/glycidamide binding to spermatid protamines, causing dominant lethality and effects on sperm morphology; and (2) acrylamide binding to motor proteins, causing distal axonopathy, including hindlimb weakness/paresis, and effects on mounting, sperm motility, and intromission. Glycidamide-induced mutations appear to play no role in reproductive or neurologic toxicity.
机译：丙烯酰胺单体会引起啮齿类动物周围神经毒性，致突变性，致分裂性，雄性生殖毒性，产前致死率和与内分泌有关的肿瘤。丙烯酰胺（和/或其代谢产物缩水甘油酰胺）与多巴胺受体和精子精蛋白结合，并抑制驱动蛋白和达因的活性，从而干扰神经元细胞内转运和精子运动。糖苷酰胺结合各种蛋白质和DNA。低剂量的丙烯酰胺可减少产仔数，老鼠比老鼠更敏感。高剂量时，精子的形态，运动性和神经毒性受到影响，从而降低了交配频率。丙烯酰胺不影响雌性生殖（雌性表现出神经毒性）。重大的致死突变导致新生儿产仔数减少。作用机理似乎是：（1）丙烯酰胺/缩水甘油酰胺与精子鱼精蛋白结合，引起主要的致死性并影响精子的形态。 （2）丙烯酰胺与运动蛋白结合，引起远端轴突病，包括后肢无力/轻瘫，并影响坐骑，精子运动和内分泌。糖苷酰胺诱导的突变似乎在生殖或神经毒性中不起作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号