Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4

Jan Ohotski; Hugh Rosen; Robert Bittman; Susan Pyne; Nigel J. Pyne

首页> 外文期刊>Cellular Signalling >Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4

【24h】

Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4

机译：鞘氨醇激酶2阻止鞘氨醇1-磷酸受体2和酪氨酸416磷酸化的c-Src的核易位并增加雌激素受体阴性MDA-MB-231乳腺癌细胞的生长：鞘氨醇1-磷酸受体4的作用

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We demonstrate that pre-treatment of estrogen receptor negative MDA-MB-231 breast cancer cells containing ectopically expressed HA-tagged sphingosine 1-phosphate receptor-2 (S1P_2) with the sphingosine kinase 1/2 inhibitor SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) or the sphingosine kinase 2 selective inhibitor (R)-FTY720 methyl ether (ROMe) or sphingosine kinase 2 siRNA induced the translocation of HA-tagged S1P_2 and Y416 phosphorylated c-Src to the nucleus of these cells. This is associated with reduced growth of HA-tagged S1P_2 over-expressing MDA-MB-231 cells. Treatment of HA-S1P2 over-expressing MDA-MB-231 cells with the sphingosine 1-phosphate receptor-4 (S1P_4) antagonist CYM50367 or with S1P_4 siRNA also promoted nuclear translocation of HA-tagged S1P_2. These findings identify for the first time a signaling pathway in which sphingosine 1-phosphate formed by sphingosine kinase 2 binds to S1P_4 to prevent nuclear translocation of S1P_2 and thereby promote the growth of estrogen receptor negative breast cancer cells.

机译：我们证明了鞘氨醇激酶1/2抑制剂SKi（2-（对-羟基苯胺基）含有雌激素受体阴性MDA-MB-231乳腺癌细胞的异位表达的HA-标记的鞘氨醇1-磷酸受体2（S1P_2）的预处理）-4-（对氯苯基）噻唑）或鞘氨醇激酶2选择性抑制剂（R）-FTY720甲醚（ROMe）或鞘氨醇激酶2 siRNA诱导HA标记的S1P_2和Y416磷酸化的c-Src向核转移这些细胞。这与过表达HA标签的S1P_2过表达的MDA-MB-231细胞的生长减少有关。用鞘氨醇1-磷酸受体4（S1P_4）拮抗剂CYM50367或用S1P_4 siRNA处理过表达HA-S1P2的MDA-MB-231细胞也促进了HA标记的S1P_2的核易位。这些发现首次确定了由鞘氨醇激酶2形成的鞘氨醇1-磷酸与S1P_4结合以阻止S1P_2的核易位并从而促进雌激素受体阴性乳腺癌细胞生长的信号通路。

著录项

来源
《Cellular Signalling》 |2014年第5期|共8页
作者
Jan Ohotski; Hugh Rosen; Robert Bittman; Susan Pyne; Nigel J. Pyne;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞形态学;
关键词
Sphingosine 1-phosphate; Sphingosine 1-phosphate receptors; Sphingosine kinase; Cancer; Growth; Nuclear signaling;

机译：1-磷酸鞘氨醇;1-磷酸鞘氨醇受体;鞘氨醇激酶;癌症;生长;核信号;

相似文献

外文文献
中文文献
专利

1. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4 [J] . Jan Ohotski, Hugh Rosen, Robert Bittman, Cellular Signalling . 2014,第5期

机译：鞘氨醇激酶2阻止鞘氨醇1-磷酸受体2和酪氨酸416磷酸化的c-Src的核易位并增加雌激素受体阴性MDA-MB-231乳腺癌细胞的生长：鞘氨醇1-磷酸受体4的作用
2. High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. [J] . Watson C, Long JS, Orange C, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2010,第5期

机译：鞘氨醇1-磷酸受体，S1P1和S1P3，鞘氨醇激酶1和细胞外信号调节激酶-1/2的高表达与雌激素受体阳性乳腺癌患者中他莫昔芬耐药性的发展有关。
3. High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients [J] . Carol Watson, Jaclyn S. Long, Clare Orange, The American journal of pathology. . 2010,第5期

机译：鞘氨醇1-磷酸受体，S1P1和S1P3，鞘氨醇激酶1和细胞外信号调节激酶1/2的高表达与雌激素受体阳性乳腺癌患者他莫昔芬耐药性的发展有关。
4. The Role of Sphingosine 1-Phosphate Receptors in the Trafficking of Hematopoietic Progenitor Cells [C] . GABRIELE SEITZ, ANDREAS M. BOEHMLER, LOTHAR KANZ, International Conference and Workshop on Hematopoietic Stem Cells . 2005

机译：鞘氨酸1-磷酸盐受体在造血祖细胞贩运中的作用
5. Sphingosine Kinase-2/Sphingosine 1-Phosphate Signaling Regulates Telomerase in Lung Cancer. [D] . Panneer Selvam, Shanmugam. 2013

机译：Sphingosine Kinase-2 / Sphingosine 1-磷酸信号调节肺癌中的端粒酶。
6. Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells [O] . Jaclyn S. Long, Joanne Edwards, Carol Watson, 2010

机译：鞘氨醇激酶1诱导对人类表皮生长因子受体2的耐受性并防止雌激素受体阳性乳腺癌细胞中鞘氨醇1-磷酸的迁移表型的形成。
7. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth : the role of sphingosine 1-phosphate receptor-4 [O] . Ohotski, Jan, Rosen, Hugh, Bittman, Robert, 2014

机译：鞘氨醇激酶2阻止鞘氨醇1-磷酸受体2和酪氨酸416磷酸化c-Src的核易位并增加雌激素受体阴性MDA-MB-231乳腺癌细胞的生长：鞘氨醇1-磷酸受体4的作用

Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4

摘要

著录项

相似文献

相关主题

期刊订阅