Cycloheximide-induced cPLA(2) activation is via the MKP-1 down-regulation and ERK activation

Lin WW.; Hsu YW.

首页> 外文期刊>Cellular Signalling >Cycloheximide-induced cPLA(2) activation is via the MKP-1 down-regulation and ERK activation

【24h】

Cycloheximide-induced cPLA(2) activation is via the MKP-1 down-regulation and ERK activation

机译：环己酰亚胺诱导的cPLA（2）激活是通过MKP-1下调和ERK激活

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Extracellular signal-regulated kinase (ERK)-dependent phosphorylation is an important regulator for cytosolic phospholipase A(2) (cPLA(2)) In this study, we found that the protein synthesis inhibitor cycloheximide can potentiate thapsigargin-induced arachidonic acid (AA) release concomitant with ERK phosphorylation from murine RAW 264.7 rmacrophages. The cycloheximide effect is not due to the activation of p38 mitogen-activated protein kinase (MAPK) nor c-Jun NH2-terminal kinase (JNK), because the activator of both MAPKs anisomycin does not elicit AA release. Cycloheximide effect is additive to the tyrosine phosphatase inhibitor orthovanadate since these two stimuli induced sustained ERK activation respectively through inhibition of the translation and activity of MAPK phosphatase-1 (MKP-1). (C) 2000 Elsevier Science Inc. All rights reserved. [References: 28]

机译：细胞外信号调节激酶（ERK）依赖的磷酸化是胞质磷脂酶A（2）（cPLA（2））的重要调节剂。从鼠RAW 264.7巨噬细胞释放伴随ERK磷酸化的蛋白。环己酰亚胺的作用不是由于p38丝裂原活化蛋白激酶（MAPK）的激活，也不是c-Jun NH2末端激酶（JNK）的激活，因为这两种MAPK茴香霉素的激活剂均不会引起AA释放。由于这两种刺激分别通过抑制MAPK磷酸酶-1（MKP-1）的翻译和活性而诱导了持续的ERK活化，因此环己酰亚胺的作用与酪氨酸磷酸酶抑制剂原钒酸盐相加。（C）2000 Elsevier Science Inc.保留所有权利。 [参考：28]

著录项

来源
《Cellular Signalling》 |2000年第7期|共5页
作者
Lin WW.; Hsu YW.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞形态学;
关键词
Cycloheximide; Orthovanadate; Erk; Cpla(2); Mkp-1; Macrophage; Cytosolic phospholipase a(2); Protein-kinase phosphatase-1; Dual-specificity phosphatase; Tumor-necrosis-factor; Map kinase; Arachidonic-acid; Tyrosine-phosphatase; Endothelial-cells; Growth-factor; In-vivo;

机译：环己酰亚胺;原钒酸酯;Erk;Cpla（2）;Mkp-1;巨噬细胞;胞质磷脂酶a（2）;蛋白激酶磷酸酶-1;双特异性磷酸酶;肿瘤坏死因子;Map激酶;花生四烯酸;酪氨酸磷酸酶;内皮细胞;生长因子;体内;

相似文献

外文文献
中文文献
专利

1. Cycloheximide-induced cPLA(2) activation is via the MKP-1 down-regulation and ERK activation [J] . Lin WW., Hsu YW. Cellular Signalling . 2000,第7期

机译：环己酰亚胺诱导的cPLA（2）激活是通过MKP-1下调和ERK激活
2. Activation of extracellular signal-regulated kinase (ERK) and induction of mitogen-activated protein kinase phosphatase 1 (MKP-1) by perifused thyrotropin-releasing hormone (TRH) stimulation in rat pituitary GH3 cells. [J] . Oride A, Kanasaki H, Mutiara S, Molecular and Cellular Endocrinology . 2008,第1a2期

机译：在大鼠垂体GH3细胞中通过促溶促甲状腺激素释放激素（TRH）刺激来激活细胞外信号调节激酶（ERK）并诱导丝裂原激活的蛋白激酶磷酸酶1（MKP-1）。
3. Compartment-specific regulation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) by ERK-dependent and non-ERK-dependent inductions of MAPK phosphatase (MKP)-3 and MKP-1 in diff [J] . Reffas S., Schlegel W. The Biochemical Journal . 2000,第Pta3期

机译：通过ERK依赖性和非ERK依赖性MAPK磷酸酶（MKP）诱导，对细胞外信号调节激酶（ERK）和c-Jun N端激酶（JNK）丝裂原激活的蛋白激酶（MAPK）进行室特异性调节3和MKP-1在差异
4. Effect of Acidic Activated Natural Zeolite on Characteristics of Bio Oil Derived from Pinus Merkusii's Cone Pyrolysis [C] . Ariany Zulkania, Achmad Chafidz, Putri Maharani International Conference on Applied Engineering, Materials and Mechanics . 2019

机译：酸性活化天然沸石对Pinus Merkusii锥热解的生物油特性的影响
5. Mitogen Activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) is a Critical Negative Regulator of Staphylococcus aureus Induced Inflammatory Cytokine Gene Expression in Macrophages [D] . Bechill, Michael Paul 2014

机译：丝裂原活化蛋白（MAP）激酶磷酸酶-1（MKP-1）是金黄色葡萄球菌诱导的巨噬细胞中炎性细胞因子基因表达的关键负调控因子。
6. Phosphorylation of Protein Kinase Cδ on Distinct Tyrosine Residues Induces Sustained Activation of Erk1/2 via Down-regulation of MKP-1 [O] . Stephanie L. Lomonaco, Sarit Kahana, Michal Blass, 2008

机译：不同酪氨酸残基上蛋白激酶Cδ的磷酸化通过下调MKP-1诱导Erk1 / 2的持续激活。
7. Phosphorylation of Protein Kinase Cδ on Distinct Tyrosine Residues Induces Sustained Activation of Erk1/2 via Down-regulation of MKP-1: ROLE IN THE APOPTOTIC EFFECT OF ETOPOSIDE* [O] . Lomonaco, Stephanie L., Kahana, Sarit, Blass, Michal, 2008

机译：不同酪氨酸残基上蛋白激酶Cδ的磷酸化通过下调MKP-1诱导Erk1 / 2的持续激活：ROLE 在细胞凋亡的作用负离子*

Cycloheximide-induced cPLA(2) activation is via the MKP-1 down-regulation and ERK activation

摘要

著录项

相似文献

相关主题

期刊订阅