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首页> 外文期刊>Cellular Signalling >RAFTK/Pyk2-mediated cellular signalling [Review]
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RAFTK/Pyk2-mediated cellular signalling [Review]

机译：RAFTK / Pyk2介导​​的细胞信号传导[综述]

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摘要

Intracellular signal transduction following extracellular ligation by a wide variety of surface molecules involves the activation and tyrosine phosphorylation of protein tyrosine kinases (PTKs). Tyrosine phosphorylation, controlled by the coordinated actions of protein tyrosine phosphatases (PTPs) and tyrosine kinases, is a critical regulatory mechanism for various physiological processes, including cell growth, differentiation, metabolism, cell cycle regulation and cytoskeleton function. The focal adhesion PTK family consists of the focal adhesion kinase (FAK) and the RAFTK/Pyk2 kinase (also known as CAK-beta and CADTK). RAFTK/Pyk2 can be activated by a variety of extracellular signals that elevate intracellular calcium concentration, and by stress signals. RAFTK/Pyk2 is expressed mainly in the central nervous system and in cells derived from hematopoietic lineages, while FAK is widely expressed in various tissues and links transmembrane integrin receptors to intracellular pathways. This review describes the role of RAFTK/Pyk2 in Various signalling cascades and details the differential signalling by FAK and RAFTK/Pyk2. (C) 2000 Elsevier Science Inc. All rights reserved. [References: 90]
机译：各种表面分子进行细胞外连接后的细胞内信号转导涉及蛋白质酪氨酸激酶（PTK）的激活和酪氨酸磷酸化。酪氨酸磷酸化受蛋白质酪氨酸磷酸酶（PTP）和酪氨酸激酶的协同作用控制，是各种生理过程（包括细胞生长，分化，代谢，细胞周期调节和细胞骨架功能）的关键调节机制。粘着斑PTK家族由粘着斑激酶（FAK）和RAFTK / Pyk2激酶（也称为CAK-beta和CADTK）组成。 RAFTK / Pyk2可以被多种升高细胞内钙浓度的细胞外信号以及应激信号激活。 RAFTK / Pyk2主要在中枢神经系统和造血谱系衍生的细胞中表达，而FAK在各种组织中广泛表达并将跨膜整合素受体与细胞内途径联系起来。这篇综述描述了RAFTK / Pyk2在各种信号级联中的作用，并详细介绍了FAK和RAFTK / Pyk2的差分信号。 （C）2000 Elsevier Science Inc.保留所有权利。 [参考：90]

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