Exploring the cell signalling in hepatocyte differentiation

Vasconcellos Rebecca; Alvarenga Erika C.; Parreira Ricardo C.; Lima Swiany S.; Resende Rodrigo R.

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Exploring the cell signalling in hepatocyte differentiation

机译：探索肝细胞分化中的细胞信号传导

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The liver is the second largest organ in the human body and is responsible for several functions that directly contribute to homeostasis. Hepatocytes are the main parenchymal liver cells that regulate multiple biochemical and metabolic functions and the synthesis of substances important to the body. Mesenchymal stem cells (MSCs) are a group of stem cells derived from the mesoderm, which can be obtained from various tissues. Under certain conditions, MSCs can differentiate into several cell types, including hepatocytes. Post-transcriptional regulations of liver development signalling and hepatocyte differentiation have been demonstrated. At the post-transcriptional level, microRNAs have emerged as precursors for determining cell fate during differentiation. MicroRNAs (miRNAs) are small non-coding RNAs involved in the post-transcriptional regulation of gene expression. They can determine the stem cell fate by repressing the translation of target mRNAs. In this review, we outline signalling pathways involved in stem cell differentiation to hepatocytes and its interplay with liver development. Hepatic differentiation models in two-dimensional and three-dimensional cultures used to analyse signalling mechanisms will be described. We also highlight the possible miRNAs involved in this process and the transdifferentiation signalling mechanisms present in hepatocytes. (C) 2016 Elsevier Inc. All rights reserved.

机译：肝脏是人体第二大器官，负责多种直接促进体内平衡的功能。肝细胞是主要的实质肝细胞，可调节多种生化和代谢功能以及对人体重要的物质的合成。间充质干细胞（MSC）是一组源自中胚层的干细胞，可以从各种组织中获得。在某些条件下，MSC可以分化为几种细胞类型，包括肝细胞。肝脏发育信号和肝细胞分化的转录后调控已得到证明。在转录后水平，microRNA已成为确定分化过程中细胞命运的前体。 MicroRNA（miRNA）是参与基因表达的转录后调控的小型非编码RNA。他们可以通过抑制靶标mRNA的翻译来确定干细胞的命运。在这篇综述中，我们概述了干细胞向肝细胞分化及其与肝脏发育相互作用的信号通路。将描述用于分析信号传导机制的二维和三维文化中的肝分化模型。我们还强调了可能参与此过程的miRNA和肝细胞中存在的转分化信号传导机制。（C）2016 Elsevier Inc.保留所有权利。

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《Cellular Signalling》 |2016年第11期|共16页
作者
Vasconcellos Rebecca; Alvarenga Erika C.; Parreira Ricardo C.; Lima Swiany S.; Resende Rodrigo R.;
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正文语种 eng
中图分类细胞形态学;
关键词
miRNA; Stem cells differentiation; Hepatocytes; Liver development; Cell signalling;

机译：miRNA;干细胞分化;肝细胞;肝发育;细胞信号转导;

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1. Exploring the cell signalling in hepatocyte differentiation [J] . Vasconcellos Rebecca, Alvarenga Erika C., Parreira Ricardo C., Cellular Signalling . 2016,第11期

机译：探索肝细胞分化中的细胞信号传导
2. Hepatocyte growth factor-induced differentiation of bone mesenchymal stem cells toward hepatocyte-like cells occurs through nuclear factor-kappa B signaling in vitro [J] . Yang Tongxi, Wang Yi, Jiang Shasha, Cell biology international. . 2016,第9期

机译：通过体外核因子-Kappa B信号发生肝细胞生长因子诱导的骨间充质干细胞对肝细胞样细胞的分化
3. Co-culture of B-13 hepatocyte progenitors with liver myofibroblasts promotes progenitor WNT signalling repression in response to glucocorticoids and enhances their transdifferentiation towards hepatocyte-like cells [J] . Fairhall Emma, Wallace Karen, Wright Matthew Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2014,第Null期

机译：B-13肝细胞祖细胞与肝成纤维细胞的共培养可促进对糖皮质激素的祖细胞WNT信号抑制，并增强其向类肝细胞的转分化能力
4. 3D Transdifferentiation of Human Mesenchymal Stem Cells into Hepatocyte-Like Cells Using Bioprinted Scaffolds [C] . Chien KB, Jakus AE, Shah RN Society for Biomaterials annual meeting and exposition . 2013

机译：使用生物印染的支架将人间充质干细胞从3D转分化为类肝细胞
5. Engineering a three-dimensional culture system for the directed differentiation of pluripotent stem cells toward a hepatocyte-like cell fate. [D] . Owens, Derek Jason. 2012

机译：设计一个用于将多能干细胞定向分化为肝细胞样细胞命运的三维培养系统。
6. Direct transdifferentiation of spermatogonial stem cells to morphological phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A cyclin B and cyclin E [O] . Zhenzhen Zhang, Yuehua Gong, Ying Guo, 2013

机译：通过ERK1 / 2和Smad2 / 3信号通路将精原干细胞直接转分化为形态学表型和功能性肝细胞样细胞并使cyclin Acyclin B和cyclin E失活
7. Hepatocyte Growth Factor-induced Differentiation of BMSCs toward Hepatocyte-like Cells via the NF-κB and P38MAPK Signaling Pathway [O] . Yingying Li, Ling Li, Yi WANG, 2017

机译：通过NF-κB和P38MAPK信号通路肝细胞生长因子诱导BMSCs对肝细胞样细胞的分化
8. Light and Electron Microscopic Comparisons of Normal Hepatocytes and Neoplastic Hepatocytes of Well-Differentiated Hepotocellular Carcinomas in a Teleost Fish [R] . Couch, J. A. 1993

机译：正常肝细胞和匀染鱼中分化良好的肝细胞癌的肿瘤肝细胞的光和电子显微镜比较

Exploring the cell signalling in hepatocyte differentiation

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