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首页> 外文期刊>Cellular Signalling >Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention
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Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention

机译：芹菜素抑制紫外线辐射的角质形成细胞中的mTOR：预防皮肤癌的新含义

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Ultraviolet B (UVB) radiation is the major environmental risk factor for developing skin cancer, the most common cancer worldwide, which is characterized by aberrant activation of Akt/mTOR (mammalian target of rapamycin). Importantly, the link between UV irradiation and mTOR signaling has not been fully established. Apigenin is a naturally occurring flavonoid that has been shown to inhibit UV-induced skin cancer. Previously, we have demonstrated that apigenin activates AMP-activated protein kinase (AMPK), which leads to suppression of basal mTOR activity in cultured keratinocytes. Here, we demonstrated that apigenin inhibited UVB-induced mTOR activation, cell proliferation and cell cycle progression in mouse skin and in mouse epidermal keratinocytes. Interestingly, UVB induced mTOR signaling via PI3K/Akt pathway, however, the inhibition of UVB-induced mTOR signaling by apigenin was not Akt-dependent. Instead, it was driven by AMPK activation. In addition, mTOR inhibition by apigenin in keratinocytes enhanced autophagy, which was responsible, at least in part, for the decreased proliferation in keratinocytes. In contrast, apigenin did not alter UVB-induced apoptosis. Taken together, our results indicate the important role of mTOR inhibition in UVB protection by apigenin, and provide a new target and strategy for better prevention of UV-induced skin cancer. (C) 2016 Elsevier Inc. All rights reserved.
机译：紫外线B（UVB）辐射是发展皮肤癌（世界上最常见的癌症）的主要环境风险因素，其特征是Akt / mTOR（雷帕霉素的哺乳动物靶标）异常活化。重要的是，紫外线照射与mTOR信号传导之间的联系尚未完全建立。芹菜素是一种天然存在的类黄酮，已被证明能抑制紫外线诱发的皮肤癌。以前，我们已经证明芹菜素可以激活AMP激活的蛋白激酶（AMPK），从而抑制培养的角质形成细胞中基础mTOR活性。在这里，我们证明芹菜素在小鼠皮肤和小鼠表皮角质形成细胞中抑制UVB诱导的mTOR活化，细胞增殖和细胞周期进程。有趣的是，UVB通过PI3K / Akt途径诱导mTOR信号转导，然而，芹菜素对UVB诱导的mTOR信号转导的抑制不是Akt依赖性的。相反，它是由AMPK激活驱动的。此外，芹菜素在角质形成细胞中对mTOR的抑制作用增强了自噬，这至少部分是导致角质形成细胞增殖减少的原因。相反，芹菜素不改变UVB诱导的细胞凋亡。综上所述，我们的结果表明芹菜素对mTOR抑制在紫外线保护中的重要作用，并为更好地预防紫外线诱发的皮肤癌提供了新的目标和策略。 （C）2016 Elsevier Inc.保留所有权利。

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