Perifosine sensitizes UVB-induced apoptosis in skin cells: New implication of skin cancer prevention?

Ji C.; Yang Y.-L.; Yang Z.; Tu Y.; Cheng L.; Chen B.; Xia J.-P.; Sun W.-L.; Su Z.-L.; He L.; Bi Z.-G.

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Perifosine sensitizes UVB-induced apoptosis in skin cells: New implication of skin cancer prevention?

机译：Perifosine增强UVB诱导的皮肤细胞凋亡：预防皮肤癌的新含义？

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We demonstrate here that a relative low dose of perifosine significantly enhanced UVB-induced apoptosis in skin cells (keratinocytes and fibroblasts), associated with a significant increase of reactive oxygen species (ROS) and ceramide production as well as multiple perturbations of diverse cell signaling pathways, shifting to a significant pro-apoptosis outcomes. Perifosine inhibited UVB-induced pro-survival Akt/mammalian target of rapamycin (mTOR) and ERK activation, while facilitating pro-apoptotic AMP-activated protein kinas (AMPK), c-Jun-NH _2-kinase (JNK), and p53 activation; these signaling changes together promoted a striking increase in skin cell apoptosis and a significantly reduced amount of DNA damages. Our results suggest that perifosine may represent a novel skin cancer prevention strategy.

机译：我们在这里证明了相对较低剂量的过磷s碱显着增强了UVB诱导的皮肤细胞（角质形成细胞和成纤维细胞）凋亡，与活性氧（ROS）和神经酰胺产生的显着增加以及多种细胞信号通路的多重扰动有关，转移至明显的促凋亡结果。 Perifosine抑制UVB诱导的雷帕霉素（mTOR）和ERK激活的生存Akt /哺乳动物靶标，同时促进促凋亡的AMP激活的蛋白激酶（AMPK），c-Jun-NH _2激酶（JNK）和p53激活;这些信号改变共同促进了皮肤细胞凋亡的显着增加，并显着减少了DNA损伤的数量。我们的结果表明，periposine可能代表了一种新型的皮肤癌预防策略。

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《Cellular Signalling》 |2012年第9期|共9页
作者
Ji C.; Yang Y.-L.; Yang Z.; Tu Y.; Cheng L.; Chen B.; Xia J.-P.; Sun W.-L.; Su Z.-L.; He L.; Bi Z.-G.;
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正文语种 eng
中图分类细胞形态学;
关键词
Apoptosis; Perifosine; Signal transduction; Skin cancer; UV radiation;

机译：凋亡;perifosine;信号传导;皮肤癌;紫外线辐射;

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专利

1. Perifosine sensitizes UVB-induced apoptosis in skin cells: New implication of skin cancer prevention? [J] . Ji C., Yang Y.-L., Yang Z., Cellular Signalling . 2012,第9期

机译：Perifosine增强UVB诱导的皮肤细胞凋亡：预防皮肤癌的新含义？
2. Sargaquinoic acid and sargachromenol, extracts of Sargassum sagamianum, induce apoptosis in HaCaT cells and mice skin: Its potentiation of UVB-induced apoptosis. [J] . Hur S, Lee H, Kim Y, European Journal of Pharmacology: An International Journal . 2008,第1a3期

机译：鼠尾草提取物海藻酸和海藻色素，可诱导HaCaT细胞和小鼠皮肤的细胞凋亡：增强UVB诱导的细胞凋亡。
3. Liquiritin suppresses UVB-induced skin injury through prevention of inflammation, oxidative stress and apoptosis through the TLR4/MyD88/NF-kappa B and MAPK/caspase signaling pathways [J] . Li Xiao-Qing, Cai Li-Min, Liu Jing, International journal of molecular medicine . 2018,第3期

机译：通过TLR4 / MyD88 / NF-Kappa B和MAPK / Caspase信号传导途径防止炎症，氧化应激和凋亡，Lealiritin通过预防炎症，氧化应激和凋亡来抑制UVB诱导的皮肤损伤
4. Ugonin K induces Cell Cycle Arrest and Apoptosis through Reactive oxygen species/Apoptosis Signal Pathway in Human Skin Cancer Cells [C] . Leong-Perng Chan, Tzung-Han Chou, Guey-Horng Wang, International Conference on Manufacturing Science and Engineering . 2013

机译：Ugonin K通过在人体皮肤癌细胞中的活性氧物质/凋亡信号途径诱导细胞周期停滞和细胞凋亡
5. Folate nutrition in human skin: Implications for cancer prevention. [D] . Williams, Joshua David. 2010

机译：人类皮肤中的叶酸营养：对预防癌症的意义。
6. C/EBPα Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBPα Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas [O] . Elizabeth A. Thompson, Songyun Zhu, Jonathan R. Hall, -1

机译：C /EBpα表达下调人类非黑色素瘤皮肤癌和C /EBpα赋予易感性的失活到UVB诱发的皮肤鳞状细胞癌
7. C/EBPα Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBPα Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas [O] . Thompson Elizabeth A., Zhu Songyun, Hall Jonathan R., 2011

机译：C /EBPα表达在人类非黑素瘤皮肤癌中下调，并且C /EBPα的失活赋予UVB诱导的皮肤鳞状细胞癌敏感性。

Perifosine sensitizes UVB-induced apoptosis in skin cells: New implication of skin cancer prevention?

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