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首页> 外文期刊>Cell transplantation >Effectiveness of acidic oxidative potential water in preventing bacterial infection in islet transplantation.
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Effectiveness of acidic oxidative potential water in preventing bacterial infection in islet transplantation.

机译：酸性氧化电位水在胰岛移植中预防细菌感染的有效性。

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摘要

At a number of points in the current procedures of islet isolation and islet culture after the harvesting of donor pancreata, microorganisms could potentially infect the islet preparation. Furthermore, the use of islets from multiple donors can compound the risks of contamination of individual recipients. Acidic oxidative potential water (also termed electrolyzed strong acid solution, function water, or acqua oxidation water), which was developed in Japan, is a strong acid formed on the anode in the electrolysis of water containing a small amount of sodium chloride. It has these physical properties: pH, from 2.3 to 2.7; oxidative-reduction potential, from 1,000 to 1,100 mV; dissolved chlorine, from 30 to 40 ppm; and dissolved oxygen, from 10 to 30 ppm. Because of these properties, acidic oxidative potential water has strong bactericidal effects on all bacteria including methicillin-resistant Staphylococcus aureus (MRSA), viruses including HIV, HBV, HCV, CMV, and fungi as a result of the action of the active oxygen and active chlorine that it contains. We conducted this study to evaluate the effect of acidic oxidative potential water irrigation on bacterial contamination on the harvesting of porcine pancreata from slaughterhouses for islet xenotransplantation by counting the number of pancreatic surface bacteria using the Dip-slide method, and on the results of islet culture; and to evaluate the direct effect on isolated islets when it is used to prevent bacterial contamination by the static incubation test and by morphological examination. Direct irrigation of the pancreas by acidic oxidative potential water was found to be very effective in preventing bacterial contamination, but direct irrigation of isolated islets slightly decreased their viability and function.
机译：在当前的胰岛分离和收获供体胰腺后的胰岛培养过程中的许多方面，微生物都可能感染胰岛制剂。此外，使用来自多个供体的胰岛会加重单个受体受污染的风险。在日本开发的酸性氧化势水（也称为电解强酸溶液，功能水或acqua氧化水）是在电解过程中在含有少量氯化钠的水中电解时在阳极上形成的强酸。它具有以下物理特性：pH值从2.3到2.7;氧化还原电位为1,000至1,100 mV;溶解氯为30至40 ppm;溶解氧为10至30 ppm。由于这些特性，酸性氧化性势能水通过活性氧和活性物质的作用对包括耐甲氧西林的金黄色葡萄球菌（MRSA），包括HIV，HBV，HCV，CMV和真菌在内的病毒在内的所有细菌具有强杀菌作用。它所含的氯。我们进行了这项研究，以评估通过使用Dip-Slide方法计算胰腺表面细菌的数量，评估酸性氧化水灌溉对细菌污染对从胰岛进行异种移植的猪胰腺收获的影响，以及对胰岛培养结果的影响。 ;并通过静态孵化试验和形态学检查评估分离出的胰岛用于预防细菌污染时的直接作用。发现用酸性氧化势水直接冲洗胰腺在预防细菌污染方面非常有效，但是直接冲洗孤立的胰岛会稍微降低其生存能力和功能。

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