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Regulation of exocytosis in adrenal chrornaffin cells: focus on ARF and Rho GTPases [Review]

机译：肾上腺软骨蛋白细胞胞吐作用的调节：专注于ARF和Rho GTPases [综述]

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摘要

Neurons and neuroendocrine cells release transmitters and hormones by exocytosis, a highly regulated process in which secretory vesicles or granules fuse with the plasma membrane to release their contents in response to a calcium trigger. Several stages have been recognized in exocytosis. After recruitment and docking at the plasma membrane, vesicles/granules enter a priming step, which is then followed by the fusion process. Cortical actin remodelling accompanies the exocytotic reaction, but the links between actin dynamics and trafficking events remain poorly understood. Here, we review the action of Rho and ADP-ribosylation factor (ARF) GTPases within the exocytotic pathway in adrenal chromaffin cells. Rho proteins are well known for their pivotal role in regulating the actin cytoskeleton. ARFs were originally identified as regulators of vesicle transport within cells. The possible interplay between these two families of GTPases and their downstream effectors provides novel insights into the mechanisms that govern exocytosis. (C) 2003 Elsevier Science Inc. All rights reserved. [References: 87]
机译：神经元和神经内分泌细胞通过胞吐作用释放出递质和激素，这是一个高度受控的过程，在该过程中，分泌性囊泡或颗粒与质膜融合，以响应钙触发而释放其内容物。在胞吐作用中已经认识到几个阶段。在募集并停靠在质膜后，囊泡/颗粒进入引发步骤，然后进行融合过程。皮质肌动蛋白重塑伴随着胞吐反应，但肌动蛋白动力学和运输事件之间的联系仍然知之甚少。在这里，我们审查肾上腺嗜铬细胞的胞吐途径内Rho和ADP-核糖基化因子（ARF）GTPases的作用。 Rho蛋白在调节肌动蛋白细胞骨架中起关键作用。 ARF最初被确定为细胞内囊泡运输的调节剂。这两个GTPases家族及其下游效应子之间可能的相互作用为控制胞吐作用的机制提供了新颖的见解。 （C）2003 Elsevier Science Inc.保留所有权利。 [参考：87]

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