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Involvement of NF-kappa B signalling in skin physiology and disease [Review]

机译：NF-κB信号传导参与皮肤生理和疾病的研究[综述]

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摘要

Transcription factors of the nuclear factor-kappaB (NF-kappaB)/Rel family play a crucial role in gene regulation during a variety of different cellular processes. This review focuses on the increasing knowledge of the role of NF-kappaB in skin physiology and pathology. Several studies demonstrate that NF-kappaB, or components of the system such as IkappaB kinase (IKK)-alpha, seem to be involved in epidermal development and differentiation. Furthermore, a dysregulation of NF-kappaB is suggested to play an important role in skin pathology, including proliferative disorders, e.g. psoriasis, inflammatory processes such as incontinentia pigmenti (IP), sunburn, Lyme disease, allergic contact dermatitis and autoimmune diseases, as well as also in skin carcinogenesis. However, although the knowledge concerning the role of NF-kappaB in the homeostasis of the skin is steadily increasing, many more questions need to be answered. (C) 2002 Elsevier Science Inc. All rights reserved. [References: 76]
机译：核因子-kappaB（NF-kappaB）/ Rel家族的转录因子在多种不同的细胞过程中在基因调控中起着至关重要的作用。这篇综述着重于对NF-κB在皮肤生理学和病理学中的作用的认识的增加。多项研究表明，NF-kappaB或系统组件，例如IkappaB激酶（IKK）-α，似乎与表皮的发育和分化有关。此外，NF-κB的失调被认为在皮肤病理学中起重要作用，所述皮肤病理学包括增生性疾病，例如肝癌。牛皮癣，发炎过程，例如色素失禁（IP），晒伤，莱姆病，过敏性接触性皮炎和自身免疫性疾病，以及皮肤癌变。然而，尽管关于NF-κB在皮肤稳态中的作用的知识正在稳步增加，但是还需要回答更多的问题。 （C）2002 Elsevier Science Inc.保留所有权利。 [参考：76]

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