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Meta-analysis of the association between the IL-12B +1188 A/C polymorphism and cancer risk

机译：荟萃分析IL-12B +1188 A / C多态性与癌症风险之间的关系

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Background: Because of inconsistent results from previous studies on the association of IL-12B +1188 A/C polymorphism with cancer risk, a meta-analysis was performed to assess the association. Materials and Methods: A literature search was performed to identify all relevant studies to May 31, 2012, with a restriction to English and Chinese publications. Pooled data were estimated using a random-effects model. Results: 17 publications were included in the meta-analysis. The results indicated that the polymorphism was significantly associated with a decreased risk for overall cancer (odds ratio (OR), 95% confidence interval (CI): 0.86, 0.76-0.97, p = 0.007; 0.80, 0.68-0.95, p = 0.012; and 0.88, 0.78-0.99, p = 0.032, respectively for dominant model, recessive model, and allele analysis) or nasopharyngeal cancer and hepatocellular carcinoma. This association was also found in Asians (OR, 95% CI: 0.89, 0.80-0.99, p = 0.031; 0.82, 0.68-0.98, p = 0.027; and 0.89, 0.80-1.00, p = 0.047, respectively for dominant model, recessive model, and allele analysis), but not in Europeans and Americans. Conclusion: The present study indicates that the IL-12B +1188 A/C polymorphism could play a protective role in the development of cancer. More investigations involving various cancer types among various populations are needed.
机译：背景：由于先前关于IL-12B +1188 A / C多态性与癌症风险之间关系的研究结果不一致，因此进行了荟萃分析以评估这种关系。资料和方法：进行文献检索，以鉴定截至2012年5月31日的所有相关研究，但仅限中英文出版物。使用随机效应模型估计汇总数据。结果：荟萃分析包括17篇出版物。结果表明，多态性与总体癌症风险降低显着相关（优势比（OR），95％置信区间（CI）：0.86，0.76-0.97，p = 0.007; 0.80，0.68-0.95，p = 0.012 ;对于显性模型，隐性模型和等位基因分析，分别为0.88、0.78-0.99，p = 0.032）或鼻咽癌和肝细胞癌。在亚洲人中也发现了这种关联（对于优势模型，OR分别为95％CI：0.89、0.80-0.99，p = 0.031; 0.82、0.68-0.98，p = 0.027;以及0.89、0.80-1.00，p = 0.047，隐性模型和等位基因分析），但不适用于欧洲人和美国人。结论：本研究表明IL-12B +1188 A / C多态性可能在癌症的发展中起保护作用。需要进行更多涉及各种人群中各种癌症类型的研究。

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