The natural history of hormone receptor-positive breast cancer: attempting to decipher an intriguing concept.

Gayathri Nagaraj; Matthew J Ellis; Cynthia X Ma

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The natural history of hormone receptor-positive breast cancer: attempting to decipher an intriguing concept.

机译：激素受体阳性乳腺癌的自然史：试图破译一个有趣的概念。

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We commend Elgene Lim and colleagues for providing a comprehensive review on the natural history of hormone receptor-positive breast cancer, highlighting the molecular and clinical heterogeneity of this disease, gaps in our understanding of its underlying biology, and challenges in research and clinical practice. We echo the sentiment that progress in treatment of hormone receptor-positive breast cancer has been slow and the impact of newer endocrine therapy approaches, such as the introduction of aromatase inhibitors (AIs) in the adjuvant setting and extended adjuvant therapy, on relapse and survival has been modest. Additionally, despite progress in the molecular profiling of breast cancer and subclassi-fication of ER-positive disease into luminal A and lumi-nal B subtypes, existing molecular assays have not raised new therapeutic hypotheses.

机译：我们赞扬Elgene Lim及其同事对激素受体阳性乳腺癌的自然史进行了全面的综述，强调了该疾病的分子和临床异质性，我们对其基本生物学认识的不足以及研究和临床实践中的挑战。我们赞同这样一种观点，即激素受体阳性乳腺癌的治疗进展缓慢，并且新的内分泌治疗方法（例如在辅助治疗中引入芳香酶抑制剂（AIs）和延长辅助治疗）对复发和生存的影响一直很谦虚。另外，尽管在乳腺癌的分子谱分析和将ER阳性疾病亚类化为腔A和发光B亚型方面取得了进展，但是现有的分子测定并未提出新的治疗假说。

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《Oncology》 |2012年第8期|共3页
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Gayathri Nagaraj; Matthew J Ellis; Cynthia X Ma;
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中图分类肿瘤学;
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1. The natural history of hormone receptor-positive breast cancer: attempting to decipher an intriguing concept. [J] . Gayathri Nagaraj, Matthew J Ellis, Cynthia X Ma Oncology . 2012,第8期

机译：激素受体阳性乳腺癌的自然史：试图破译一个有趣的概念。
2. Gene expression profiling of breast cancers between high and low Ki-67 after short-term preoperative hormone therapy among hormone receptor-positive / human epidermal growth factor receptor 2-negative breast cancers with high Ki-67 [J] . Intelligence: A Multidisciplinary Journal . 2020,第期

机译：短期术前激素治疗乳腺癌患者乳腺癌在激素受体阳性/人体表皮生长因子受体2阴性乳腺癌中的短期术前激素治疗后乳腺癌的基因表达分析
3. Non-initiation of adjuvant hormonal therapy in women with hormone receptor-positive breast cancer: The Breast Cancer Quality of Care Study (BQUAL) [J] . NeugutA.I., HillyerG.C., KushiL.H., Breast cancer research and treatment. . 2012,第1期

机译：未开始激素受体阳性乳腺癌女性的辅助激素治疗：乳腺癌护理质量研究（BQUAL）
4. Estrogen Receptor-Positive Breast Cancer: Traditional Prognostics, Molecular Pathology: A New Breast Cancer Taxonomy and 21st Century Personalized Prognostic and Predictive Assays [C] . Frederick L. Baehner International Symposium on Cancer Metastasis and the Lymphovascular system: Basis for Rational Therapy . 2009

机译：雌激素受体阳性乳腺癌：传统预测，分子病理：新的乳腺癌分类和21世纪个性化预测和预测测定
5. Treatment Interruption and Discontinuation of Hormone Therapy in Hormone Receptor-Positive Breast Cancer Patients [D] . Mao, Daqin . 2020

机译：激素受体阳性乳腺癌患者中的治疗中断与激素治疗中的中断和停止
6. Triple-Negative Breast Cancers: Associations Between Imaging and Pathological Findings for Triple-Negative Tumors Compared With Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor-2-Negative Breast Cancers [O] . Martine Boisserie-Lacroix, Gaëtan MacGrogan, Marc Debled, 2013

机译：三阴性乳腺癌：与激素受体阳性/人表皮生长因子受体-2-阴性乳腺癌相比三阴性肿瘤的影像学和病理结果之间的关联
7. Steroid-hormone receptors in nonpalpable and more advanced stages of breast cancer. A contribution to the biology and natural history of carcinoma of the female breast [O] . J. G. M. Tinnemans, L. V. A. M. Beex, Th. Wobbes, 1990

机译：类固醇激素受体在非耐受性和更先进的乳腺癌阶段。对女性乳腺癌癌生物学和自然史的贡献
8. Role for MEK-Interacting Protein 1 (MP1) in Hormone Responsiveness of Estrogen Receptor-Positive Breast Cancer Cells [R] . Conrad, S. E. 2008

机译：mEK相互作用蛋白1（mp1）在雌激素受体阳性乳腺癌细胞激素反应中的作用

The natural history of hormone receptor-positive breast cancer: attempting to decipher an intriguing concept.

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