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首页> 外文期刊>Oncology letters >Local hyperthermia for esophageal cancer in a rabbit tumor model: Magnetic stent hyperthermia versus magnetic fluid hyperthermia
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Local hyperthermia for esophageal cancer in a rabbit tumor model: Magnetic stent hyperthermia versus magnetic fluid hyperthermia

机译：兔肿瘤模型中食管癌的局部热疗：支架热疗与磁流体热疗

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Magnetic-mediated hyperthermia (MMH) is a promising local thermotherapy approach for cancer treatment. The present study investigated the feasibility and effectiveness of MMH in esophageal cancer using a rabbit tumor model. The therapeutic effect of two hyperthermia approaches, magnetic stent hyperthermia (MSH), in which heat is induced by the clinical stent that is placed inside the esophagus, and magnetic fluid hyperthermia (MFH), where magnetic nanoparticles are applied as the agent, was systematically evaluated. A rabbit esophageal tumor model was established by injecting VX2 carcinoma cells into the esophageal submucosa. The esophageal stent was deployed perorally into the tumor segment of the esophagus. For the MFH, magnetic nanoparticles (MNPs) were administered to the rabbits by intratumoral injection. The rabbits were exposed under a benchtop applicator using an alternative magnetic field (AMF) with 300 kHz frequency for the hyperthermia treatment. The results demonstrated that esophageal stents and MNPs had ideal inductive heating properties upon exposure under an AMF of 300 kHz. MSH, using a thermal dose of 46°C with a 10-min treatment time, demonstrated antitumor effects on the rabbit esophageal cancer. However, the rabbit esophageal wall is not heat-resistant. Therefore, a higher temperature or longer treatment time may lead to necrosis of the rabbit esophagus. MFH has a significant antitumor effect by confining the heat within the tumor site without damaging the adjacent normal tissues. The present study indicates that the two hyperthermia procedures have therapeutic effects on esophageal cancer, and that MFH may be more specific than MSH in terms of temperature control during the treatment.
机译：磁介热疗（MMH）是一种有前途的局部热疗法，可用于癌症治疗。本研究使用兔肿瘤模型研究了MMH在食管癌中的可行性和有效性。系统地对两种热疗方法的治疗效果进行了系统性的治疗：磁性支架热疗（MSH）和磁性液体纳米热疗（MFH），其中磁性支架被放置在食道内，该支架通过放置在食道内部的热量来产生热量。评估。通过将VX2癌细胞注入食管粘膜下层来建立兔食管肿瘤模型。食道支架经口部署到食道的肿瘤部分。对于MFH，通过瘤内注射将磁性纳米颗粒（MNP）给予兔子。将兔子暴露于台式敷抹器下，使用频率为300 kHz的交流磁场（AMF）进行热疗。结果表明，在300 kHz的AMF下暴露时，食管支架和MNP具有理想的感应加热性能。 MSH使用46°C的热剂量，治疗时间为10分钟，证明对兔食道癌具有抗肿瘤作用。但是，兔食管壁不耐热。因此，较高的温度或较长的治疗时间可能导致兔食道坏死。 MFH通过将热量限制在肿瘤部位内而不损坏相邻的正常组织而具有显着的抗肿瘤作用。本研究表明，这两种热疗程序对食道癌具有治疗作用，并且在治疗过程中就温度控制而言，MFH可能比MSH更具特异性。

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