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首页> 外文期刊>Oncology letters >N-myc downstream-regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)
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N-myc downstream-regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)

机译：N-myc下游调控基因1：人类肝细胞癌的多种功能和复杂功能（综述）

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摘要

N-myc downstream-regulated gene 1 (NDRG1) has been reported to be a multifunctional protein associated with carcinogenesis and tumor progression. However, the cellular function of NDRG1 remains elusive in human hepatocellular carcinoma (HCC). No NDRG1 expression is observed in normal liver tissue. Overexpression of NDRG1 has been observed in human HCC, particularly with aggressive invasion, metastasis, poor differentiation and short patient survival. In addition, recent studies have shown that NDRG1 exhibits an inhibitory effect on HCC growth in vitro and in vivo, which contrasts with previous reports indicating that NDRG1 promotes the proliferation and invasion of HCC cell lines. Further studies have shown that the localization of NDRG1 is variable, translocating to the nucleus or membrane according to the cell state, which may relate to the diverse function of NDRG1. The present study reviews our current knowledge with regard to the functions of NDRG1 in HCC and other types of human cancer.
机译：N-myc下游调控基因1（NDRG1）已被报道是一种与癌变和肿瘤进展相关的多功能蛋白。但是，NDRG1的细胞功能在人类肝细胞癌（HCC）中仍然难以捉摸。在正常肝组织中未观察到NDRG1表达。 NDRG1的过表达已在人类肝癌中观察到，特别是侵袭性侵袭，转移，分化差和患者生存期短。此外，最近的研究表明，NDRG1在体外和体内均表现出对HCC生长的抑制作用，这与以前的报道表明NDRG1促进HCC细胞系的增殖和侵袭形成了对比。进一步的研究表明，NDRG1的定位是可变的，根据细胞状态易位至核或膜，这可能与NDRG1的多种功能有关。本研究回顾了我们目前有关NDRG1在肝癌和其他类型人类癌症中的功能的知识。

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