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首页> 外文期刊>Oncology letters >Effects of tubeimoside-1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro
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Effects of tubeimoside-1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro

机译：Tubeimoside-1对BGC823胃癌细胞体外增殖和凋亡的影响。

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摘要

Natural products isolated from Chinese medicinal herbs are useful sources of new drugs for cancer therapy. Tubeimoside-1 (TBMS1) is a natural compound isolated from the Chinese medicinal herb Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae). Studies have shown that TBMS1 has anticancer effects in various human cancer cell lines. However, the effect of TBMS1 on human gastric cancer cells is unknown. In the present study, it was observed that TBMS1 inhibited BGC823 gastric cancer cell proliferation in a concentration- and time-dependent manner. Fluorescent microscopy and flow cytometric analysis showed that TBMS1 induced BGC823 cell apoptosis in a concentration-dependent manner. Western blot analysis also showed that TBMS1 induced apoptosis by regulation of the Bcl-2 gene family in BGC823 cells. These findings indicate that TBMS1 may be developed as a possible therapeutic agent for the management of gastric cancer.
机译：从中草药中分离出的天然产物是用于癌症治疗的新药的有用来源。 Tubeimoside-1（TBMS1）是从中草药Bolbostemma paniculatum（Maxim。）Franquet（葫芦科）分离得到的天然化合物。研究表明，TBMS1在多种人类癌细胞系中具有抗癌作用。但是，TBMS1对人胃癌细胞的作用尚不清楚。在本研究中，观察到TBMS1以浓度和时间依赖性方式抑制BGC823胃癌细胞的增殖。荧光显微镜和流式细胞仪分析表明，TBMS1以浓度依赖的方式诱导BGC823细胞凋亡。蛋白质印迹分析还显示，TBMS1通过调节BGC823细胞中的Bcl-2基因家族来诱导凋亡。这些发现表明，TBMS1可能被开发为胃癌治疗的可能治疗剂。

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