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首页> 外文期刊>Oncology letters >Overexpression of high mobility group box 1 and 2 is associated with the progression and angiogenesis of human bladder carcinoma
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Overexpression of high mobility group box 1 and 2 is associated with the progression and angiogenesis of human bladder carcinoma

机译：高迁移率族框1和2的过表达与人膀胱癌的进展和血管生成有关

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High mobility group box 1 (HMGB1) and HMGB2 overexpression has been observed in several human tumor types, and is involved in cancer progression and prognosis. However, the clinicopathological significance of HMGB1 and HMGB2 expression in bladder carcinoma (BCa), particularly the involvement of these proteins in angiogenesis, remains unclear. In the present study, immunohistochemistry and real-time polymerase chain reaction (PCR) of HMGB1 and HMGB2 in 64 BCa patients revealed that HMGB1 and HMGB2 were overexpressed in BCa tissues compared with normal tissues, and were correlated with tumor clinical stage and pathological grade. In addition, correlation analysis of vascular endothelial growth factor (VEGF) and microvessel density (MVD) counts indicated that the overexpression of HMGB1 and HMGB2 was also correlated with angiogenesis. We conclude that HMGB proteins act as key regulators in the progression and angiogenesis of bladder carcinoma, and serve as potential diagnostic and therapeutic targets.
机译：在几种人类肿瘤类型中已观察到高迁移率族框1（HMGB1）和HMGB2的过表达，它们参与了癌症的进展和预后。但是，HMGB1和HMGB2在膀胱癌（BCa）中的表达在临床病理上的意义，尤其是这些蛋白在血管生成中的作用尚不清楚。在本研究中，HMGB1和HMGB2的免疫组织化学和实时聚合酶链反应（PCR）在64例BCa患者中显示，HMGB1和HMGB2在BCa组织中与正常组织相比过表达，并与肿瘤的临床分期和病理分级相关。此外，对血管内皮生长因子（VEGF）和微血管密度（MVD）计数的相关分析表明，HMGB1和HMGB2的过表达也与血管生成相关。我们得出的结论是，HMGB蛋白在膀胱癌的进展和血管生成中起着关键的调节剂作用，并作为潜在的诊断和治疗靶标。

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