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首页> 外文期刊>Oncology letters >Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer
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Expression and clinical significance of cyclin kinase subunit 2 in colorectal cancer

机译：细胞周期蛋白激酶亚基2在大肠癌中的表达及其临床意义

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摘要

The overexpression of cyclin kinase subunit 2 (CKS2) is tightly correlated with tumor aggressiveness and prognosis in various malignancies, including gastric, breast, liver and prostate cancer. However, whether CKS2 is upregulated in colorectal cancer (CRC) remains unknown. The aim of the present study was to analyze CKS2 expression levels in CRC, and to determine the clinical diagnostic and prognostic values of CKS2 overexpression in CRC patients. CKS2 expression was analyzed at the mRNA and protein levels by quantitative (q)PCR and western blot analysis. CKS2 expression was significantly upregulated in CRC compared with the adjacent non-cancer and normal colorectal tissues. The overexpression of CKS2 was correlated with poor differentiation and the pathological stage. In addition, CKS2 overexpression was correlated with aggressive tumor progression in CRC, which indicated that CKS2 may serve as a good CRC biomarker.
机译：细胞周期蛋白激酶亚基2（CKS2）的过表达与各种恶性肿瘤（包括胃癌，乳腺癌，肝癌和前列腺癌）的侵袭性和预后紧密相关。然而，CKS2是否在结直肠癌（CRC）中上调仍然未知。本研究的目的是分析CRC中CKS2表达水平，并确定CRC患者CKS2过表达的临床诊断和预后价值。通过定量（q）PCR和蛋白质印迹分析在mRNA和蛋白水平上分析了CKS2的表达。与邻近的非癌组织和正常结直肠组织相比，CRC中CKS2的表达显着上调。 CKS2的过表达与分化差和病理分期有关。另外，CKS2的过表达与CRC中侵袭性的肿瘤进展相关，这表明CKS2可能是良好的CRC生物标志物。

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