• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oncology letters >Dasatinib inhibits primary melanoma cell proliferation through morphology-dependent disruption of Src-ERK signaling
【24h】

Dasatinib inhibits primary melanoma cell proliferation through morphology-dependent disruption of Src-ERK signaling

机译：达沙替尼通过依赖形态的Src-ERK信号传导破坏来抑制原发性黑素瘤细胞增殖

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

New strategies for the treatment of advanced melanoma are urgently required. The RAS/RAF/MAPK pathway and c-Src are deregulated in the majority of malignant melanomas, suggesting that they may interact functionally and are involved in the development and progression of the malignancy. Preclinical studies have demonstrated variable inhibition of melanoma cell growth by dasatinib in vitro. Src may act through different downstream signaling pathways. In the present study, we demonstrate that dasatinib induces changes in cell morphology, characterized by an arborized and contracted appearance, and accompanied by a reduction in cell proliferation in primary melanoma cells. This morphological change is demonstrated to be associated with the inhibition of nuclear translocation of activated ERK1/2. Together, these results indicate that Src may promote cell proliferation through the activation of the ERK signaling pathway in melanoma oncogenesis.
机译：迫切需要治疗晚期黑素瘤的新策略。 RAS / RAF / MAPK途径和c-Src在大多数恶性黑色素瘤中均失控，表明它们可能在功能上相互作用，并参与恶性肿瘤的发生和发展。临床前研究表明达沙替尼在体外可抑制黑素瘤细胞生长。 Src可能通过不同的下游信号通路起作用。在本研究中，我们证明了dasatinib诱导细胞形态的改变，其特征是树突状和收缩的外观，并伴有原发性黑素瘤细胞增殖的减少。已证明这种形态变化与抑制活化的ERK1 / 2的核易位有关。总之，这些结果表明，Src可能通过激活黑色素瘤肿瘤发生中的ERK信号通路来促进细胞增殖。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号