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首页> 外文期刊>Oncology letters >Effect of DLK1 on tumorigenesis in CD34(+)CD38(-) bone marrow cells in myelodysplastic syndromes
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Effect of DLK1 on tumorigenesis in CD34(+)CD38(-) bone marrow cells in myelodysplastic syndromes

机译：DLK1对骨髓增生异常综合征CD34（+）CD38（-）骨髓细胞肿瘤发生的影响

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摘要

The myelodysplastic syndromes (MDSs) are a group of clonal stem cell disorders resulting from aberrations within hematopoietic stem cells (HSCs), which may lead to the onset of a number of diseases, including acute myeloid leukemia (AML). Recent studies have demonstrated that the expression levels of the DLK1 gene are increased in MDS. In order to determine whether the addition of DLK1 affects tumorigenesis, small interfering (si)RNAs were designed to target DLK1 in order to knockdown its expression in CD34(+)CD38(-) bone marrow cells in MDS. A lower proliferative rate was observed in the CD34(+)CD38(-) bone marrow cells following this knockdown of DLK1 expression. The suppression of DLK1 expression resulted in a less aggressive MDS phenotype, which suggests that the upregulation of DLK1 expression may play an oncogenic role in CD34(+)CD38(-) bone marrow cells.
机译：骨髓增生异常综合症（MDS）是一组由造血干细胞（HSC）畸变引起的克隆性干细胞疾病，可能导致许多疾病的发作，包括急性髓细胞性白血病（AML）。最近的研究表明，DLS1基因的表达水平在MDS中增加。为了确定DLK1的添加是否影响肿瘤发生，设计了小干扰（si）RNA靶向DLK1，以敲低其在MDS中CD34（+）CD38（-）骨髓细胞中的表达。敲低DLK1表达后，在CD34（+）CD38（-）骨髓细胞中观察到较低的增殖率。 DLK1表达的抑制导致侵略性MDS表型，这表明DLK1表达的上调可能在CD34（+）CD38（-）骨髓细胞中发挥致癌作用。

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