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首页> 外文期刊>Cellular and Molecular Bioengineering >Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells (vol 3, pg 30, 2010)
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Stochastic Dynamics of Membrane Protrusion Mediated by the DOCK180/Rac Pathway in Migrating Cells (vol 3, pg 30, 2010)

机译:DOCK180 / Rac途径介导的细胞迁移过程中膜突出的随机动力学(2010年第3卷,第30页)

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摘要

In our previously published article, 2 we described a computational model and analysis investigating the stochastic dynamics of cell protrusion during cell migration. In that work, we presented results of stochastic simulations plotted in two-dimensional parameter space. To supplement this analysis, the associated region of model bistability was identi?ed by analysis of the deterministic model equations, and this region was plotted on the same graphs (panels a & b in each of Figs. 2–6). Since publication of our article, we became aware that certain parameter combinations thought to lie in the bistable region are, in fact, monostable. We wish to thank Dr. Michael Savageau (Biomedical Engineering, UC Davis), who studied our model during the preparation of his review article, 1 for bringing the matter to our attention. We traced the error to the use of incorrect values of certain parameters in the bistability analysis. Whereas the values reported in the paper are correct for the stochastic model results, the bistability analysis was performed using three incorrect parameter values as shown in Table C1.
机译:在我们先前发表的文章2中,我们描述了一种计算模型和分析,用于研究细胞迁移过程中细胞突起的随机动力学。在这项工作中,我们介绍了在二维参数空间中绘制的随机模拟结果。为了补充此分析,通过确定性模型方程式分析确定了模型双稳态的相关区域,并将该区域绘制在相同的图形上(图2–6中的面板a和b)。自从我们的文章发表以来,我们意识到某些被认为位于双稳态区域的参数组合实际上是单稳态的。我们要感谢Michael Savageau博士(加州大学戴维斯分校生物医学工程系),他在撰写其评论文章1期间研究了我们的模型,并引起了我们的注意。我们将错误归因于在双稳态分析中使用某些参数的不正确值。尽管论文中报告的值对于随机模型结果是正确的,但使用表C1中所示的三个不正确的参数值进行了双稳态分析。

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