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The Role of Heat Shock Proteins in the Stimulation of an Immune Response

机译:热激蛋白在刺激免疫反应中的作用

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Heat shock proteins (HSP) have been defined as immunodominant, although most of them are highly conserved and ubiquitously distributed. Members of the 60, 70 and 90 kDa HSP families are involved in important aspects of viral and bacterial infections, in autoimmune diseases and in cancer immunity. HSP act as immunological target structures either by themselves because of an unusual expression pattern, or they are carrier proteins for immunogenic peptides. In addition to a classical major histocompatibility complex (MHC) restricted T cell response, a major contribution in the recognition of heat shock proteins has been shown for non-MHC restricted effector cells including γ/δ TcR positive T lymphocytes and natural killer (NK) cells.
机译:虽然大多数热休克蛋白(HSP)高度保守且分布广泛,但已被定义为具有免疫力的蛋白。 60、70和90 kDa HSP家族的成员参与病毒和细菌感染,自身免疫性疾病和癌症免疫的重要方面。 HSP自身由于异常的表达模式而充当免疫学靶标结构,或者它们是免疫原性肽的载体蛋白。除了经典的主要组织相容性复合物(MHC)限制的T细胞反应外,对于非MHC限制的效应细胞(包括γ/δTcR阳性T淋巴细胞和自然杀手(NK)),热识别蛋白的识别也有重要贡献。细胞。

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