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首页> 外文期刊>Oncology Research >Relationship between FDG uptake and expressions of glucose transporter type 1, type 3, and hexokinase-II in Reed-Sternberg cells of Hodgkin lymphoma.
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Relationship between FDG uptake and expressions of glucose transporter type 1, type 3, and hexokinase-II in Reed-Sternberg cells of Hodgkin lymphoma.

机译：霍奇金淋巴瘤的Reed-Sternberg细胞中FDG摄取与葡萄糖转运蛋白1型，3型和己糖激酶II的表达之间的关系。

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摘要

Reed-Sternberg (R-S) cells are the main tumor cells of Hodgkin lymphoma (HL). HL has been reported to demonstrate a high level of [18F]2-fluoro-2-deoxy-D-glucose (FDG) uptake, but the determinant of FDG uptake for HL has not been well elucidated. Thus, we investigated the relationship of FDG uptake and the expressions of glucose transporter type 1 (Glut-1), glucose transporter type 3 (Glut-3), and hexokinase II (HK-II) in R-S cells of HL. There were 25 tissue-proven HL patients from January 2003 to July 2007 in our hospital. Of the 25 HL patients, 4 cases obtained by surgical excision were included in the present study. The immunostaining for Glut-1, Glut-3, and HK-II was conducted in the excised masses. The maximum standardized uptake values (maxSUVs) were compared to the expressions of Glut-1, Glut-3, and HK-II. Three HL patients (mixed cellularity = 2 and nodular sclerosis = 1) demonstrated moderate-strong expressions of Glut-1 in almost all R-S cells, and of these three HL patients, two underwent FDG-PET, which revealed a high level of maxSUVs (7.7, 6.5) in the corresponding HL lesions. One HL patient (lymphocyte depletion) showed weak Glut-1 expressions in only 10% of R-S cells, but no FDG-PET study was available. The expressions of Glut-3 and HK-II were various in all four HL patients, and no specific correlations with FDG uptake were found. In conclusion, high expressions of Glut-1 in R-S cells may play a crucial role for the high FDG uptake in Hodgkin lymphoma.
机译：Reed-Sternberg（R-S）细胞是霍奇金淋巴瘤（HL）的主要肿瘤细胞。据报道，HL具有高水平的[18F] 2-氟-2-脱氧-D-葡萄糖（FDG）摄取，但是尚未充分阐明HL的FDG摄取决定因素。因此，我们调查了HL的R-S细胞中FDG摄取与葡萄糖转运蛋白1型（Glut-1），葡萄糖转运蛋白3型（Glut-3）和己糖激酶II（HK-II）的表达之间的关系。 2003年1月至2007年7月，我院收治了25例经组织验证的HL患者。在25例HL患者中，本研究包括4例通过手术切除获得的病例。 Glut-1，Glut-3和HK-II的免疫染色在切除的组织中进行。将最大标准化摄取值（maxSUVs）与Glut-1，Glut-3和HK-II的表达进行比较。三名HL患者（混合细胞密度= 2和结节性硬化= 1）在几乎所有RS细胞中均表现出Glut-1的中等强度表达，在这三名HL患者中，两名接受了FDG-PET检查，显示出高水平的maxSUVs（ 7.7，6.5）中相应的HL病变。一名HL患者（淋巴细胞耗竭）仅在10％的R-S细胞中显示出弱的Glut-1表达，但尚无FDG-PET研究。 Glut-3和HK-II在所有4名HL患者中的表达均不同，未发现与FDG摄取有特定的相关性。总之，R-S细胞中Glut-1的高表达可能对霍奇金淋巴瘤的高FDG摄取起关键作用。

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