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首页> 外文期刊>Oncology Research >Suppression of prometastatic phenotype of highly metastatic androgen-independent rat prostate cancer MLL cell line by PI3K inhibitor LY294002.
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Suppression of prometastatic phenotype of highly metastatic androgen-independent rat prostate cancer MLL cell line by PI3K inhibitor LY294002.

机译:PI3K抑制剂LY294002抑制高度转移性雄激素非依赖性大鼠前列腺癌MLL细胞系的转移前表型。

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摘要

Upregulation of the PI3K pathway has often been reported in androgen-independent prostate cancer and is implicated in cancer cell survival and proliferation in the absence of androgen. Inhibition of PI3K by LY294002 suppressed cell invasion and motility of the highly metastatic androgen-independent Dunning rat prostate cancer MLL cell line with similar IC50 values and inhibition profile. Moreover, LY294002 attenuated expression of urokinase plasminogen activator (uPA) without any significant effect on that of matrix metalloproteinase 2. These results indicated that the role of PI3K in MLL cell invasion is by regulating cell motility and uPA expression.
机译:在雄激素非依赖性前列腺癌中经常报道PI3K途径的上调,并且在不存在雄激素的情况下与癌细胞的存活和增殖有关。 LY294002对PI3K的抑制作用可抑制高度转移性雄激素非依赖性Dunning大鼠前列腺癌MLL细胞系的细胞侵袭和运动,且IC50值和抑制谱相似。此外,LY294002减弱了尿激酶纤溶酶原激活物(uPA)的表达,而对基质金属蛋白酶2没有明显影响。这些结果表明PI3K在MLL细胞侵袭中的作用是通过调节细胞运动性和uPA表达。

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