...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oncology Research >Genetic polymorphism in UDP-glucuronosyltransferase 2B7 and colorectal cancer risk.
【24h】

Genetic polymorphism in UDP-glucuronosyltransferase 2B7 and colorectal cancer risk.

机译：UDP-葡萄糖醛酸转移酶2B7中的遗传多态性和结直肠癌的风险。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Colorectal cancer (CRC) is one of the most common malignancies in the Western world. CRC is strongly associated with lifestyle factors. Susceptibility to CRC may be partly due to deficient detoxification capacity in the gastrointestinal tract. Genetic polymorphisms in detoxification enzymes result in variations in detoxification activities, which might influence the levels of carcinogens in the gastrointestinal tract, influencing the risk for CRC. To determine whether a genetic polymorphism in the detoxification enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) predisposes to CRC, 411 Caucasian patients with sporadic CRC and 600 Caucasian controls recruited from the same geographic area were genotyped for the functional UGT2B7 H268Y polymorphism. DNA was isolated and tested by a dual-color real-time polymerase chain reaction assay. Overall, no differences in genotype distributions between patients with CRC and controls were observed. When analyzed with respect to tumor location, a shift from the UGT2B7*I *2 into the UGT2B7*2*2 genotype was seen in patients with proximal CRC (OR 1.80, 95% CI 1.11-2.89). In the male patient subpopulation an even stronger association was observed (*1*1 + *1*2 vs. *2*2: OR 2.17, 95% CI 1.11-4.04; *1*2 vs. *2*2: OR 2.19, 95% CI 1.10-4.37). No associations with respect to tumor stage were seen. In conclusion, the frequency of the UGT2B7*2*2 genotype is higher in CRC patients with proximal location of the tumor, especially in males, which suggests that this genotype is associated with an increased risk for proximal CRC.
机译：大肠癌（CRC）是西方世界最常见的恶性肿瘤之一。 CRC与生活方式因素密切相关。 CRC的易感性可能部分归因于胃肠道的排毒能力不足。排毒酶中的遗传多态性导致排毒活动发生变化，这可能会影响胃肠道中致癌物的水平，从而影响CRC的风险。为了确定排毒酶UDP-葡萄糖醛酸转移酶2B7（UGT2B7）的遗传多态性是否易患CRC，对411名散发性CRC的白种人患者和从同一地区招募的600名白种人对照进行了基因型分析，以了解其功能性UGT2B7 H268Y多态性。分离DNA并通过双色实时聚合酶链反应测定法进行测试。总体而言，在CRC患者和对照组之间没有观察到基因型分布的差异。分析肿瘤位置时，在近端CRC患者中观察到从UGT2B7 * I * 2转变为UGT2B7 * 2 * 2基因型（OR 1.80，95％CI 1.11-2.89）。在男性患者亚群中观察到更强的关联性（* 1 * 1 + * 1 * 2 vs. * 2 * 2：OR 2.17，95％CI 1.11-4.04; * 1 * 2 vs. * 2 * 2：OR 2.19，95％CI 1.10-4.37）。没有发现与肿瘤分期有关。总之，UGT2B7 * 2 * 2基因型的频率在具有肿瘤近端定位的CRC患者中更高，尤其是在男性中，这表明该基因型与近端CRC风险增加相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号