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首页> 外文期刊>Oncology research and treatment. >Expression of Eukaryotic Initiation Factor 3f Is Associated with Prognosis in Gastric Carcinomas
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Expression of Eukaryotic Initiation Factor 3f Is Associated with Prognosis in Gastric Carcinomas

机译：真核起始因子3f的表达与胃癌的预后相关

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Background: Eukaryotic initiation factor 3f (elF3f) expression, which plays an important role in human cancer, is significantly decreased in various types of cancers. The aim of this study was to detect the expression of elF3f in gastric carcinoma (GC), which until now has not been reported. Methods: Expression of elF3f was detected by immunohistochemistry in GC tissues and adjacent non-cancerous tissues (ANCT) from 195 patients with stage l-lll GC who underwent curative gastrectomy. Clinico-pathological results, including survival, were analyzed. Results: Expression rate of elF3f in GC and ANCT were 44.8 and 81.7% respectively. Low expression of elF3f was significantly associated with an increased serum level of carcinoma embryonic antigen (p = 0.02), but not with levels of carbohydrate antigen 19-9 (p = 0.29). elF3f levels were linked to more advanced tumor stages and likelihood of recurrence (all p < 0.05).The Kaplan-Meier survival curves indicated that decreased expression of elF3f was a significant factor for a poor prognosis for GC patients (p = 0.04). Conclusion: elF3f may play an important role in recurrence. Its function and potential as a prognostic marker should be further verified in GC.
机译：背景：在人类癌症中起重要作用的真核起始因子3f（elF3f）表达在各种类型的癌症中均显着降低。这项研究的目的是检测eIF3f在胃癌（GC）中的表达，迄今为止尚未报道。方法：采用免疫组织化学方法检测了195例行根治性胃切除术的Ⅲ-Ⅲ期GC患者的GC组织和邻近非癌组织（ANCT）中的elF3f表达。分析了包括生存期在内的临床病理结果。结果：elF3f在GC和ANCT中的表达率分别为44.8和81.7％。 eIF3f的低表达与癌胚抗原的血清水平升高（p = 0.02）显着相关，但与碳水化合物抗原19-9（p = 0.29）无关。 eIF3f水平与更晚期的肿瘤分期和复发可能性相关（所有p <0.05）.Kaplan-Meier生存曲线表明，eIF3f的表达降低是GC患者预后不良的重要因素（p = 0.04）。结论：elF3f可能在复发中起重要作用。它的功能和作为预后标志物的潜力应在GC中进一步验证。

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