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首页> 外文期刊>Oncology research and treatment. >Clinicopathologic Significance of Nuclear Factor-kB and Vascular Endothelial Growth Factor Expression in Advanced Gastric Cancer Patients
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Clinicopathologic Significance of Nuclear Factor-kB and Vascular Endothelial Growth Factor Expression in Advanced Gastric Cancer Patients

机译：晚期胃癌患者核因子-kB和血管内皮生长因子表达的临床病理意义

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Background: Nuclear factor-KB (NF-kB) and vascular endothelial growth factor (VEGF) are involved in cell proliferation, invasion, angiogenesis, and metastasis. The principal objective of this study was to assess the prognostic significance of NF-kB and VEGF expression in gastric cancer. Methods: Tumor tissues of 154 patients with gastric cancer, all of whom underwent potentially curative resection, were immunohistochemically evaluated using monoclonal antibodies against NF-kB and VEGF. Results: The positivity rates of NF-kB and VEGF staining were 44.2% and 39.6%, respectively. NF-kB expression in tumor tissues was significantly correlated with VEGF expression (p < 0.001). VEGF expression was related to Lauren's classification (p = 0.002), differentiation (p = 0.043), depth of invasion (p = 0.005), carcino-embryonic antigen expression (p = 0.032), and stage (p = 0.026). Univariate analysis demonstrated that NF-kB expression was significantly related to both the 5-year disease-free survival (65.2% vs. 46.4%, p = 0.007) and the 5-year overall survival (60.0% vs. 42.5%, p = 0.014). Multivariate analysis verified that NF-kB was independently associated with disease-free survival (hazard ratio: 2.082, p = 0.005) and overall survival (hazard ratio: 1.841, p = 0.008). Conclusion: NF-kB expression in tumor tissue is associated with poor survival in gastric cancer patients.
机译：背景：核因子-κB（NF-kB）和血管内皮生长因子（VEGF）与细胞增殖，侵袭，血管生成和转移有关。这项研究的主要目的是评估NF-kB和VEGF在胃癌中的预后意义。方法：使用抗NF-kB和VEGF的单克隆抗体对154例胃癌患者的肿瘤组织进行了可能的根治性切除，并进行了免疫组织化学评估。结果：NF-kB和VEGF染色的阳性率分别为44.2％和39.6％。肿瘤组织中的NF-kB表达与VEGF表达显着相关（p <0.001）。 VEGF表达与Lauren的分类（p = 0.002），分化（p = 0.043），浸润深度（p = 0.005），癌胚抗原表达（p = 0.032）和阶段（p = 0.026）有关。单因素分析表明NF-kB表达与5年无病生存率（65.2％对46.4％，p = 0.007）和5年总生存率（60.0％对42.5％，p = 0.014）。多变量分析证实，NF-kB与无病生存（危险比：2.082，p = 0.005）和总生存（危险比：1.841，p = 0.008）独立相关。结论：胃癌患者肿瘤组织中NF-kB的表达与生存不良有关。

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