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Soft tissue sarcoma: An update on systemic treatment options for patients with advanced disease

机译:软组织肉瘤:晚期疾病的全身治疗选择的更新

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摘要

Sarcomas are a group of rare solid tumours arising from mesenchymal or connective tissue. This review focuses on soft tissue sarcoma and covers general topics such as the epidemiology, age distribution, site of disease, histogenesis, histological subtypes, prognosis and outcome of treatment. In more detail, the article reviews current systemic treatment standards and selected adverse events of agents such as doxorubicin, ifosfamide, trabectedin and pazopanib, and briefly highlights some drugs that are used off-label in specific subtypes of sarcoma.
机译:肉瘤是由间质或结缔组织引起的一组罕见的实体瘤。这篇综述着重于软组织肉瘤,涵盖了诸如流行病学,年龄分布,疾病部位,组织发生,组织学亚型,预后和治疗结果等一般主题。更详细地讲,本文回顾了当前的全身治疗标准以及诸如阿霉素,异环磷酰胺,曲贝汀和帕唑帕尼等药物的某些不良事件,并简要介绍了在肉瘤的特定亚型中非标签使用的某些药物。

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