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首页> 外文期刊>Research in Microbiology >Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia.
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Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia.

机译：群体感应抑制剂的使用可干扰伯克霍尔德菌和伯克霍尔德菌新菌的生物膜形成和发育。

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Burkholderia cepacia complex strains are opportunistic pathogens causing life-threatening infections in cystic fibrosis patients. B. cepacia complex strains are resistant to many antimicrobial agents and commonly produce biofilms in vitro and in vivo. This contributes to their virulence and makes Burkholderia infections difficult to treat. Recently, the quorum sensing (QS) system of Burkholderia spp. has been found to affect their biofilm-forming ability, making it an attractive target for antimicrobial therapy. However, detailed information about the anti-biofilm effect of these compounds is still lacking. In the present study, we evaluated the anti-biofilm effect of several known QS inhibitors. The effect on Burkholderia spp. biofilm formation was examined using crystal violet, resazurin and SYTO9 staining, confocal laser scanning microscopy as well as plating. When used at subinhibitory concentrations, several compounds interfered with biofilm formation by Burkholderia spp. Our results suggest that the QS inhibitors affect later stages of biofilm formation and detachment.
机译：伯克霍尔德菌洋葱伯克霍尔德菌复合体菌株是机会性病原体，在囊性纤维化患者中引起威胁生命的感染。洋葱伯克霍尔德菌复合菌株对许多抗菌剂具有抗性，通常在体外和体内产生生物膜。这会增加其毒力，并使伯克霍尔德氏菌感染难以治疗。最近，伯克霍尔德氏菌的群体感应（QS）系统。已发现其影响生物膜形成能力，使其成为抗微生物治疗的有吸引力的靶标。但是，仍然缺少有关这些化合物的抗生物膜作用的详细信息。在本研究中，我们评估了几种已知QS抑制剂的抗生物膜作用。对伯克霍尔德氏菌的影响。使用结晶紫，刃天青和SYTO9染色，共聚焦激光扫描显微镜以及平板检查生物膜的形成。当以亚抑制浓度使用时，几种化合物会干扰伯克霍尔德菌属物种的生物膜形成。我们的结果表明，QS抑制剂会影响生物膜形成和分离的后期阶段。

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