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首页> 外文期刊>Ophthalmic Research: Journal for Research in Experimental and Clinical Ophthalmology >Comparison between one injection and three monthly injections of intravitreal bevacizumab for myopic choroidal neovascularization
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Comparison between one injection and three monthly injections of intravitreal bevacizumab for myopic choroidal neovascularization

机译：玻璃体内贝伐单抗单次注射和每月三次注射治疗近视脉络膜新生血管的比较

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摘要

Aim: To compare the effects of one intravitreal bevacizumab (IVB) injection with three monthly injections for myopic choroidal neovascularization. Methods: Group A included 13 patients treated with one IVB injection; group B included 19 patients treated with three monthly 1.25-mg IVB injections. All patients were followed monthly for 12 months with additional injections performed as needed. The best-corrected visual acuity (BCVA) and the central foveal thickness (CFT) on optical coherence tomography were evaluated before and after treatment. Results: The mean logMAR BCVA improved from 0.59 to 0.49 at 12 months in group A (p = 0.21) and from 0.65 to 0.29 in group B (p < 0.001); the improved logMAR BCVA differed significantly between the groups (p < 0.05). The mean CFT decreased from 231 μm at baseline to 150 μm at 12 months in group A (p < 0.05) and from 279 to 156 μm in group B (p < 0.001). During the follow-up, 6 of 13 eyes in group A and 5 of 19 eyes in group B received additional injections. Conclusions: Treatment starting with three monthly IVB injections may achieve better functional outcomes with fewer retreatments compared with treatment starting with one IVB injection.
机译：目的：比较一次玻璃体内贝伐单抗（IVB）注射与三个月一次注射对近视脉络膜新生血管形成的影响。方法：A组包括13例接受一次IVB注射治疗的患者。 B组包括19例接受3次每月1.25 mg IVB注射治疗的患者。所有患者每月随访12个月，并根据需要进行其他注射。在治疗前后，对光学相干断层扫描的最佳矫正视力（BCVA）和中央凹中央厚度（CFT）进行评估。结果：A组在12个月时的平均logMAR BCVA从0.59改善至0.49（p = 0.21），B组从0.65改善至0.29（p <0.001）;两组之间改进的logMAR BCVA有显着差异（p <0.05）。 A组的平均CFT从基线时的231μm降至12个月时的150μm（p <0.05），B组从279降至156μm（p <0.001）。在随访期间，A组13只眼中的6只眼和B组19只眼中的5只接受了额外的注射。结论：与一次IVB注射开始的治疗相比，以每月3次IVB注射开始的治疗可能获得更好的功能结果，并且减少了再治疗。

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